Wednesday, March 23, 2011

Mouthwash

A medicated solution used for rinsing and gargling the mouth resulting in increased oral hygiene.

Lozenge

It is a type of candy or small pellet which is medicated or aromatic. It is intended for slow dissolution in the mouth and often a demulcent is used in lozenges i.e. a substance helpful in soothing the mucus membrane which is inflamed.

Cefpirome

It is a 4th generation cephalosporin.

Action:
It binds to penicillin binding protein and inhibits peptidoglycan synthesis in bacterial cell wall.

Uses:
It is active against gram positive and gram negative bacteria and is used for the treatment of lower respiratory tract infections and upper and lower urinary tract infections.

Cefozopran

It is a 4th generation cephalosporin. It is used parenterally.

Uses:
It is used against respiratory tract infections and urinary tract infections.

Cefepime

It is a 4th generation cephalosporin.

Action:
It has same action as that of other beta lactam antibiotics such as penicillin.

Uses:
It has an extended spectrum of activity against gram-positive and gram-negative bacteria and is used for the treatment of pneumonia and urinary tract infections.

Ceftobiprole

It is a fifth generation cephalosporin.

Action:
It inhibits penicillin binding proteins.

Uses:
It is used against infections caused by staphylococcus, streptococcus and enterococci.

Telithromycin

It is a ketolide antibiotic. It is derived from erythromycin.

Action:
It binds to 23S rRNA of the 50S ribosomal subunit of the bacteria having 25 times more affinity for macrolide resistant strains.

Uses:
It is used for the treatment of acute sinusitis, acute bronchitis and acute bacterial tonsilitis.

Cethromycin

It is a ketolide antibiotic.

Uses:It is an orphan drug for the treatment of post exposure inhalational anthrax. Research is on the way for its use in community acquired pneumonia (CAP).

Ansamycin

It is a ketolide antibiotic.

Action:
It inhibits DNA dependent RNA polymerase activity.

Uses:
It is used against many gram positive bacteria and some gram negative bacteria.

Sorangicin-A

It is a broad spectrum macrolide antibiotic. It is isolated from Sorangium cellulosum.

Quinopristin/dalfopristin

It is a macrolide antibiotic.

Action:
Dalfopristin binds to 23S portion of 50S ribosomal subunit and Quinopristin binds to a nearby site of 50S ribosomal subunit and in this way they causes the inhibition of protein synthesis.

Uses:It is used for the treatment of Staphylococcal infections and infections caused by Enterococcus faecium.

Pristinamycin

It is a macrolide antibiotic.

Uses:It is used in the treatment of staphylococcal infections and to some extent for streptococcal infections.

Lincomycin

It is a macrolide antibiotic.

Mechanism of Action:
It binds to 50S ribosomal subunit of bacteria and results in decreased protein synthesis.

Uses:It is used in the treatment of infections caused by staphylococcus and streptococcus.

Clindamycin

It is a macrolide antibiotic.

Mechanism of Action:
It binds to 50S ribosomal subunit of bacteria resulting in decreased protein synthesis.

Uses:It is used for osteomyelitis, dental infections and diabetic foot ulcers.

Maridomycin

It is a macrolide antibiotic.

Uses:It is an antibiotic and is also used for the Uterine myoma and endometriosis.

Kejanimicin

It is a macrolide antibiotic and is structurally related to tetrocarcin.
Kejanolide is the aglycon portion of the Kajanamicin.

Tetrocarcin

It is a macrolide antibiotic.

Action:
It inhibits Bcl2 function and thereby inhibiting the anti-apoptic activity.

Uses:It is an antibiotic with a strong antitumor activity.

Chlorothricin

It is a macrolide antibiotic.

Flurithromycin

It is macrolide antibiotic. It is a derivative of Erythromycin and is also similar in action to erythromycin.

Rokitamycin

It is a macrolide antibiotic.

Action:
It causes inhibition of the protein synthesis.

Uses:It is effectively used in the infections caused by Gram positive bacteria, E. faecalis and H. influenzae.

Miocamycin

It is a macrolide antibiotic.

Uses:It is effective in respiratory and genital infections.

Carbomycin-A

It is an similar to erythromycin.

Action:
It causes the inhibition of protein synthesis.

Troleandomycin

It is a macrolide antibiotic.It is similar to erythromycin.

Action:
It binds to 50S ribosomal subunit of bacteria resulting in inhibition of protein synthesis.

Uses:
It is used for the treatment of Pneumococcal pneumonia.

Spiramycin

It is a macrolide/ketolide antibiotic. It is an experimental drug.

Uses:It is used to treat toxoplasmosis.

Tuesday, March 22, 2011

Oleandomycin

It is a macrolide/ketolide antibiotic.

Uses:
It is used in the infections caused by Bacillus subtilis, Enterococcus faecalis and Staphylococcus aureous.

Midecamicin

It is a macrolide antibiotic.

Uses:
It inhibits staphylococci, streptococci and some species of Hemophilus.

Kitasamycin

It is a macrolide antibiotic. It is used against a wide spectrum of pathogens.

Leucoscandrolide B

It is a macrolide antibiotic.

Josamycin

It is a macrolide antibiotic. It is used against a wide spectrum of pathogens.

Mechanism of Action:
It binds reversibly to 50S ribosomal subunit of bacteria resulting in the inhibition of translocation of peptidyl tRNA.

Leucascandrolide A

It is macrolide antibiotic.It is a biologically active marine natural product.

Roxithromycin

It is a macrolide antibiotic.It is similar in action to erythromycin or azithromycin.

Dirithromycin

It is a macrolide antibiotic.

Mechanism of Action:
It binds to the 50S ribosomal subunit of bacteria resulting in the inhibition of the translocation of the peptides.

Uses:
It is used to treat bacterial infections such as tonsillitis, bronchitis and pneumonia.

Erythromycin

It is a macrolide antibiotic.

Mechanism of Action:
It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.

Uses:
It is used for the treatment of respiratory tract infections and pertussis.

Clarithromycin

It is a Macrolide antibiotic derived from erythromycin.

Mechanism of Action:
It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.

Uses:It is used for the treatment of acute otitis media and infections caused by H. influenzae and S. pneumoniae.

Azithromycin

It is a macrolide antibiotic.

Action:
It binds to 50S ribosomal subunit of bacterial ribosome resulting in the inhibition of the peptidyl transferase activity.

Uses:
It is used for the infections caused by H. Influenzae, C. Pneumoniae and S. aureus.

Vertilmicin

It is an aminoglycoside antibiotic. It is structurally very similar to netilmicin.

Uses:It is a potent bactericidal agent against E. coli, S. aureus and Klebsiella pneumoniae.

Tobramycin

It is an aminoglycoside antibiotic.

Action:
It binds to 30S ribosomal subunit inhibiting bacterial protein synthesis.

Used:
It is used in the treatment of infections caused by gram negative bacteria especially pseudomonas species.

Sisomicin

It is an aminoglycoside antibiotic derived from "Micromonospora" bacteria. It is closely related to gentamicin.

Uses:It is used in the treatment of the infections caused by Serratia and indole positive Proteus species.

Ribostamycin

It is an aminoglycoside antibiotic.

Mechanism of Action:
It binds to 30S ribosomal subunit of bacteria resulting in the reduction of the synthesis of the bacterial proteins.

Paromomycin

It is an aminoglycoside antibiotic.

Action:
It inhibits bacterial protein synthesis by binding to 16S rRNA.

Uses:It is used for the treatment of both acute as well as chronic intestinal amebiasis.

Netilmicin

It is an aminoglycoside antibiotic.It is derived from sisomycin and is similar in action to gentamicin.

Isepamicin

It is an aminoglycoside antibiotic similar in action to amikacin.

Habekacin

It is an aminoglycoside antibiotic.

It is similar in action to kanamycin and gentamicin.

Framycetin

It is an aminoglycoside and is a component of neomycin.

Mechanism of Action:
It binds to 30S subunit proteins and 16S rRNA resulting in the production of nonfunctional peptides.

Uses:It is used for the treatment of bacterial blepharitis and corneal injuries. It is also used for the treatment of Conjunctivitis.

Dibekacin

It is an aminoglycoside antibiotic.It is derived from Kanamycin B.

Uses:
It is used in the infections of E. coli and P. Aeruginosa.

Amikacin

It is an aminoglycoside antibiotic derived from Kanamycin A.

Action:
It binds to 30S ribosome of susceptible organism resulting in the inhibition of bacterial protein synthesis.

Uses:
It is used for the treatment of severe infections caused by Gram Negative Organisms including E. coli and Pseudomonas species.

Verdamicin

It is an aminoglycoside derived from "Micromonospora" bacteria.

It is similar to gentamicin.

Gentamicin

It is an aminoglycoside antibiotic derived from "Micromonospora" bacteria.

Mechanism of Action:
It binds irreversibly to 30S-subunit proteins and 16S rRNA resulting in the production of nonfunctional peptide.

Uses:
It is used to treat infections caused by E. coli and proteus species.

Spectinomycin

It is an aminoglycoside antibiotic derived from "Streptomyces" bacteria.

Mechanism of Action:
It acts on 30S ribosomal subunit resulting in the inhibition of the protein synthesis in the bacterial cell wall.

Uses:
It is used for the treatment of gonorrhea.

Hygromycin B

It is an aminoglycoside antibiotic derived from "Streptomyces" bacteria.

Action:
It inhibits polypeptide synthesis.