Mechanism of action:
They cause non-depolarizing competitive blockage of ganglia. They compete with acetylcholine at postsynaptic nicotinic receptors.
Actions:
Since the ganglia of sympathetic as well as parasympathetic nervous system are cholinergic so these agents obstruct the outflow through these systems.
Blockade of sympathetic outflow causes a decrease in firmness of the arterioles resulting in the reduced peripheral vascular resistance leading to postural or orthostatic hypotension.
Blockade of parasympathetic outflow causes:
1. A prominent reduction in the motility of the GI tract.
2. Dry mouth
3. Cycloplegia with a decrease in accommodation.
4. Precipitation of urinary retention in men with prostatic hypertrophy.
Adverse effects:
Mostly autonomic effects
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