Introduction:
It is 5-HT receptor agonist acting on 5-HT1D that innervates the intracranial vasculature.
Action:
It decreases the release of sensory neuropeptides, such as substance P.
Pharmacokinetics:
• Use orally or SC.
• Its onset of action is 20 minutes parenterally and 1-3 hours orally.
• T1/2 = 2 hrs.
It is effective in 80% of patients.
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