1. Classification according to action:
a. Dopamine D2-receptor antagonists:
Metoclopromide, Domperidone, Phenothiazines (e.g. chlorpromazine, thioridazine)
b. Sedative-hypnotics:
Barbiturates, Benzodiazepines.
c. Anti-histamines:
Promethazine, Cyclizine, Dimenhydrinate, Diphenhydramine.
d. 5-HT3 (serotonin) receptor antagonists:
Ondansetron, Tropisetron, Granisetron.
e. Anti-cholinergic:
Scopolamine
f. Demulcents:
Gum acacia, Gum tragacanth.
g. Miscellaneous:
Aprepitant, Diphenidol hydrochloride
2. Classification according to specific causes:
a. Motion sickness:
Anti-cholinergic drugs, Anti-histamines
b. Nausea and vomiting due to other causes:
i. Vomiting by cytotoxic drugs:
Phenothiazines, metoclopramide, serotonin antagonists
ii. Vomiting induced by pregnancy:
Anti-histamines, Vit. B6 alongwith anti-histamine such as meclizine
iii. Vertigo:
Cyclizine, Phenothiazine, Cinnarizine
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