Third Professional, Second Semester, Pharmacology

PHARMACOLOGY AND THERAPEUTICS-IV (Systemic Pharmacology-II)
(Theory)

Cr. Hr. 03


1. CHEMOTHERAPY

(a) Classification of drugs.

(b) Antimicrobials: Sulphonamides, Antivirals, Antiprotozoals (Treatment of Malaria and Treatment of Amebiasis), Antifungals, Anthelmintics, Anti-neoplastic and Immunosuppressive drugs, Drug treatment of Leprosy and Antibiotics (Penicillins, Cephalosporins, Aminoglycosides, Tetracyclines, Chloramphenicol, Macrolides, Quinolones and Miscellaneous Antibiotics).

(c) Antihypertensive Drugs.

(d) Steroids and Antisteroid drugs.

2. HORMONES, ANTAGONISTS AND OTHER AGENTS AFFECTING ENDOCRINE FUNCTION

(a) Endocrine function and dysfunctions.

(b) Drug used for therapy of Diabetes Mellitus: Insulins and Oral Hypoglycemic agents.

(c) Corticosteroids.

(d) Thyroid hormone and anti-thyroid drugs.

3. TOXICOLOGY

(a) Pollution and its typers (water, air, food).

(b) Poison and principle of treatment of poisoning.

(c) Poisoning (Sign & symptom and treatment): Ethanol, Barbiturates, Digitalis, Salicylides, Strychnine, Narcotics, Nicotine, Paracetamol, Benzodiazepines and Organophosphorous compounds.

(d) Chelating agents and their role in poisoning: Dimercaprol, Calcium disodium edentate, Pencillamine and Defroxamine.

Note:

1. Only an introduction will be given of the banned and obsolete drug products.

2. While dealing with Pharmacology stress should be laid to the group actions of related drugs and only important differences should be discussed of the individual drugs placed in same group.

3. Newly introducted drugs should be included in the syllabus while drugs with no clinical and therapeutic values ought to be excluded from syllabus at any time.

4. The prototype drugs in each group from the latest edition of the recommended books.

PHARMACOLOGY & THERAPEUTICS-IV (Systemic Pharmacology-II)
(Laboratory)

Cr. Hr. 01

NOTE: - Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g.

1. To identify and differentiate the effects of unknown drug on human and the nerve plexus of frog.

2. To demonstrate the effects of Acetylcholine on the Rectus abdominus muscle of frog and competitive.

3. Pharmacological antagomism by Neuromuscular blocking agent e.g. Gallamine.

4. To identify the unknown drug by performing pharmacological competitive antagonism on Rectus.

5. Abdominus muscle of Frog.

6. To study the anti-coagulant effects of Heparin and oral anti-coagulants on Rabbits.

7. To identify the unknown anti-coagulant drug using Rabbits.

8. To demonstrate the graded Dose-Response curve of Acetylcholine on Rabbit intestine.

9. To identify unknown concentration of Acetycholine from graded Dose- Response curves.
Recommended Books (Pharmacology)

1. Goodman Gillman, Pharmacological basis of therapeutics.
2. Winguard and Brody, Human Pharmacology, Mosby Year Book, Boston, 1991.
3. James M Ritter and Lionel De Levis, A Text book of Clinical Pharmacology,
4. R S Satorkar and S D Bhandarkar, Pharmacology and Pharmacotherapeutics,
5. J D Tripathy, Essential of Medical Pharmacology, Japees Brother, New Delhi,
6. D R Laurance, Clinical Pharmacology, ELBS, London, 6th Ed., 1987.
7. Katzung, B G, Basic and Clinical Pharmacology,
8. Lipponcott, Pharmacology, Lippincot William & Willkin, USA, 2001.
9. Manuchair Edabi, Pharmacology, Little Brown & Company, London, 1993.
10. Qayum A Fundamentals of Experimental Pharmacology.
11. Bertram G K, Basic and Clinical Pharmacology, Paramount Publishing Business & Professional Group, USA, 6th Ed., 1995.
12. William F Ganong, W F, Review of Medical physiology, Prentice Hall International Inc, New Jersey.