Fourth Professional, Second Semester, Pharmaceutics

PHARMACEUTICS-IX (Industrial Pharmacy-II)
(Theory)


Cr. Hr. 03

1. EMULSIONS:

Mechanical Equipments, Specific formulation Considerations and Emulsion stability.

2. SUSPENSIONS: Formulation of suspensions, Equipment used in preparation and test methods for pharmaceutical suspensions.

3. SEMISOLIDS:

Equipment used for Ointments, Pastes, Gels and Jellies. Packaging of ointments.

4. STERILE PRODUCTS:

Sterile area and its Classification, Ophthalmic ointments, Preparation of praenterals (Building, Equipment), Complete Sterility (Aseptic area), air control, (Laminar flow etc.), air locks, Environmental monitoring methods, Sterilization, Filling/Packaging (Plastic and glass containers), Added substances (Preservatives, antioxidants, solubilizer, suspending agents, buffers, stabilizers etc.), Inprocess Quality Control of Parenterals (Sterility, leakage, pyrogens, clarity etc.).

5. STANDARDIZATION OF PHARMACEUTICALS: An understanding of quality assurance system adopted in pharmaceutical industry. Good Manufacturing Practices and Current Good Manufacturing Practices.

6. PACKING & PACKAGING:

Influence of Packaging materials, Stability, Packaging Lines, Packaging Area, Packaging Equipment.

7. EQUIPMENTS USED FOR: Patches, Sprays, Implants, Sutures, Plasters and Sachet packing.

8. STUDY TOUR:

A visit to the pharmaceutical industries will be an integral part of the syllabi

PHARMACEUTICS-IX (Industrial Pharmacy-II)
(Laboratory)

Cr. Hr. 01

NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g.

1. Ampoule filling, sealing and sterilization clarity and leakage tests in injectables.

2. Capsule filling by semi automatic machines. Manufacture of sustained action drugs.

3. Tablets Tests like Disintegration. Dissolution. Friability. Hardness and thickness tests. Determination of weight variation in tablets. Density of powder. Particle size analysis.

Recommended Books

1. Lackman, Theory and Practice of Industrial Pharmacy, Verghese Publishing House, Bombay, 1987.
2. Cooper and Gunn’s, Tutorial Pharmacy, CBS Publishers & Distributors, New Delhi, 1986.
3. Bentley’s Pharmaceutical Text Book, CBS Publishers & Distributors, New Delhi, 1986.
4. Remington’s Pharmaceutical Sciences, Mack Publishing Company, USA, 2001.
5. John Sharp, Good Pharmaceutical Manufacturing Practice, Rational and Compliance.