First Professional, Second Semester, Pharmaceutics

PHARMACEUTICS-II (PHYSICAL PHARMACY-II)

(Theory)

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1. DISPERSED SYSTEM:

(a) Colloids: Types, methods of preparation, properties (optional, kinetic, electrical) Dialysis and artificial kidney, stability of colloids, protection and sensitization phenomenon and application of colloids in Pharmacy.

(b) Emulsions: Types, theories of emulsification. Emulsifying agents, their classification and stability of emulsion.

(c) Suspensions: Type, Methods of Preparation, Properties, Suspending agents, their classification and stability.

(d) Adsorption Techniques: Adsorption techniques and processes of adsorption in detail.

2. RHEOLOGY:

(a) Definition and Fundamental concept.

(b) Properties contributing to rheological behaviour.

(c) Graphic presentation of rheological data.

3. RATE and ORDER OF REACTIONS.

4. KINETIC PRINCIPLES AND STABILITY TESTING: THEORETIC

CONSIDERATIONS: Degradation:

(a) Physical Factors: Influence of pH, temperature, ionic strength, acidbase catalysis, U.V. light.

(b) Chemical Factors: Complex chemical reactions. Oxidation-reduction, hydrolysis.

PHARMACEUTICS-II (PHYSICAL PHARMACY-II)
(Laboratory)

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NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g. Determination of Emulsion systems. Determination of %age composition of solutions by specific gravity method. Determination of Partition-coefficient, surface tension, viscosity.

Recommended Books

1. Martin, Physical Pharmacy, B I Waverly PVT, Delhi, 4th Ed., 1994.

2. Cooper and Gunns Tutorial Pharmacy, CBS Publishers & Distributors, New Delhi, 1986.

3. Bentley’s Pharmaceutics, All India Traveler Book Seller, New Delhi, 1996.

4. Martin P, Bustamante, P and Chun, Physical & Chemical Principles of Pharmaceutical Science, AHC, 4th Ed., (1999), New York.

5. Martin AMN, Banker G S and Chun AHC Advances in Pharmaceutical Sciences. Academic Press, London, 1985.

6. Mill C C, Casson N, Rehology of dispress systems. Pergamon Press, New York, 1975.

7. Rienger M and Scott-Blair G W, Rehology. Academic Press, London, 1990.

8. Barry B W, Advances in Pharmaceutical Sciences, Academic Press, London, 1990.

9. Sherman P. Emulsion Science, Academic Press, London, 1972.

10. Martin A, Swarbrick J and Cammatra A Physical Pharmacy, 3rd Ed., Lee & Febiger, Philadelphia, 1983.

11. Attwood D and Flocence A T, Surfactant Systems. Chapman and Hall Ltd, London, 1982.