First Professional; First Semester, Pharmaceutical Chemistry

PHARMACEUTICAL CHEMISTRY-I (ORGANIC-I)
[Theory]


Cr. Hr. 03

Note: The topics will be taught with special reference to their Pharmaceutical Applications.

1. BASIC CONCEPTS: Conjugation, hyperconjugation, steric effect, inductive effect, mesomeric effect, hydrogen bonding, Theory of resonance. Effect of structure on reactivity of compounds. Tautomerism of carbonyl compounds.

2. NUCLEOPHILIC AND ELECTROPHILIC SUBSTITUTION REACTION IN ALIPHATIC AND AROMATIC SYSTEMS.

3. ORIENTATION IN ELECTROPHILIC SUBSTITUTION REACTIONS ON BENZENE RING.

4. ORGANIC REACTIONS: Baeyer-Villiger oxidation; Diels Alder reaction; Grignard’s reaction, Metal hydride reduction and Wolf Krishner reduction, Friedel Craft’s reaction, Perkin reaction, Cannizzaro reaction, Wolf Kishner reduction.

5. CARBONIUM ION REARRANGEMENTS & THEIR STABILITY: Pinacol-pinacolone, Wagner-Meerwein, Wolf, Hofmann and Beckmann rearrangements.

6. CARBANIONS & THEIR STABILITY: Condensation reaction (Aldol condensation; Favorskii rearrangement; Witting reaction).

PHARMACEUTICAL CHEMISTRY-I (ORGANIC-I)
[Laboratory]

Cr. Hr. 01

NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g. Organic analysis: Identification of unknown simple organic compounds.

Recommended Books

1. Peter Sykes, A Guide Book to Mechanism in Organic Chemistry, Longman, New York, 1st Ed., 1991.
2. E L Eliel, Stereochemistry of Carbon Compounds, Tata MacGraw- Hill, New Delhi, 1992.
3. Rehman and M Younis, Organic Chemistry for B.Sc. students, Ilmi Kitab Khana, Lahore, 1997
4. L Finar, Organic Chemistry Vol I, Person Education Asia, 6th Ed., New Delhi, 2001.
5. Raj K Bansel, Organic Reaction Mechanism, Tata MacGraw-Hill, New Delhi, 1992.
6. Furaiss Brian, Practical Organic Chemistry, 5th Ed., ELBS, London.
7. Sykes A P, Guide Book to Mechanism in Organic Chemistry, 5th Ed., Lonsmen Co, UK, 1970.
8. Roberts J D and Caserio M C, Basic Principles of Organic Chemistry, 1990.
9. Naser-ud-Din, Introduction to Stereochemistry, Ghafoor Stationary Mart, Peshwar, 1994.
10. Bhal B S, Text Book of Organic Chemistry, S Chand & Co. New Delhi, 14th Ed., 1995.