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Friday, April 29, 2011
It is an ethyl ester of non-sulfhydryl compound, quinaprilat.
Mechanism of Action:
It is an angiotensin converting enzyme inhibitor (ACE) inhibitor. ACE is an enzyme that converts the angiotensin-I to angiotensin-II.
Peak plasma concentration of quinapril hydrochloride is found within 1 hour after administration. The extent of absorption is about 60%.
After absorption about 38% of quinapril is converted into its major active metabolite i.e. quinaprilat. About 97% of quinapril or quinaprilat is bound to plasma proteins. Uses:
It is used in hypertension and congestive heart failure.
ACE inhibitors are contraindicated in second and third trimester of pregnancy as they may cause injury and sometimes death of the developing fetus.
Accuretic (Quinapril Hydrochloride and hydrochlorothiazide)