Quinapril Hydrochloride




Credit: pfizer.com

It is an ethyl ester of non-sulfhydryl compound, quinaprilat.

Mechanism of Action:
It is an angiotensin converting enzyme inhibitor (ACE) inhibitor. ACE is an enzyme that converts the angiotensin-I to angiotensin-II.

Pharmacokinetics:
Peak plasma concentration of quinapril hydrochloride is found within 1 hour after administration. The extent of absorption is about 60%.

After absorption about 38% of quinapril is converted into its major active metabolite i.e. quinaprilat. About 97% of quinapril or quinaprilat is bound to plasma proteins.
Uses:
It is used in hypertension and congestive heart failure.

Contraindications:

ACE inhibitors are contraindicated in second and third trimester of pregnancy as they may cause injury and sometimes death of the developing fetus.

Brand Name:

Accupril
Accuretic (Quinapril Hydrochloride and hydrochlorothiazide)