Sunday, April 10, 2011

Propionic acid derivatives

Mechanism of Action:

These are reversible inhibitors of cyclooxygenase.

Action:
These inhibit the synthesis of prostaglandins but not that of leukotrienes.

Pharmacokinetics:
It is absorbed orally. It has the ability to bind to plasma albumin. It undergoes hepatic metabolism and excreted by the kidney.

Therapeutic Uses:
It is used as anti-inflammatory mostly in the chronic treatment of rheumatoid arthritis and osteoarthritis. It is also anti-pyretic and anti-inflammatory.

Adverse effects:
• Headache, tinnitus and dizziness.
• GI disturbance ranging from dyspepsia to bleeding.
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