Mechanism of Action:
These are reversible inhibitors of cyclooxygenase.
These inhibit the synthesis of prostaglandins but not that of leukotrienes.
It is absorbed orally. It has the ability to bind to plasma albumin. It undergoes hepatic metabolism and excreted by the kidney.
It is used as anti-inflammatory mostly in the chronic treatment of rheumatoid arthritis and osteoarthritis. It is also anti-pyretic and anti-inflammatory.
• Headache, tinnitus and dizziness.
• GI disturbance ranging from dyspepsia to bleeding.