Friday, April 15, 2011

Para-aminosalicylic acid

It is structurally similar to para-aminobenzoic acid (PABA).

Mechanism of action:
It competes for the enzyme involved in the conversion of PABA to dihydrpteroic acid that results in the inhibition of Purine and as a result DNA synthesis is stopped.

It is widely distributed in tissues and rapidly excreted in urine.

Its usual adult dose is 8-12 g/day orally in divided doses.

Adverse effects:
It may cause anorexia, nausea, fever and skin rashes. Furthermore, nephrotoxicity, hepatotoxicity and granulocytopenia.
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