It is structurally similar to para-aminobenzoic acid (PABA).
Mechanism of action:
It competes for the enzyme involved in the conversion of PABA to dihydrpteroic acid that results in the inhibition of Purine and as a result DNA synthesis is stopped.
Pharmacokinetics:
It is widely distributed in tissues and rapidly excreted in urine.
Dosage:
Its usual adult dose is 8-12 g/day orally in divided doses.
Adverse effects:
It may cause anorexia, nausea, fever and skin rashes. Furthermore, nephrotoxicity, hepatotoxicity and granulocytopenia.
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