Streptomycin

It is an aminoglycosides derived from "Streptomyces" bacteria.

Action:
It causes disruption in the initiation and elongation steps in protein synthesis by binding to the 30S ribosomal subunit of the the susceptible organism.

Mainly active against extracellular tubercle bacilli as it penetrates poorly into cells.

Uses:
It is used for the treatment of tuberculsosis.

Adverse effects:It is ototoxic and nephrotoxic. It may also cause vertigo and hearing loss.

Sulfasalazine

It is an antibacterial sulfonamide.

Uses:
It is used in the treatment of inflammatory bowel disease. It is also used in the treatment of rheumatoid arthritis.

Phthalylsulfathiazole

It is a antibacterial sulfonamide.

Action:
It inhibits the bacterial enzyme dihydropteroate synthetase.

Uses:
It is used to treat intestinal infections.

Sulfapyridine

It is a topical sulfonamide.

Action:
It competitively inhibits the bacterial enzyme dihydropteroate synthetase resulting in the inhibition of folic acid in bacteria.

Uses:
It is an anti-bacterial used to treat pyoderma gangrenosum and dermatitis herpetiformis.

Silver Sulfadiazine

It is a topical sulfonamide.

Action:It acts on the cell wall and cell membrane to produce a bactericidal effect.

Uses:
It is used as an adjunct in the treatment of second and third degree burns.

Mafenide

It is a topical sulfonamide.

Action:
It decreases the bacterial population  and increases the healing around the burns.

Uses:
It is used as an adjunctive treatment for serious burns.

Xipamide

It is a sulfonamide diuretic.

Action:
It decreases sodium reabsorption in the distal convoluted tubule.

Uses:
It is a thiazide like diuretic and is also used in the treatment of hypertension and edema.