Clopamide

It is a piperidine sulfonamide diuretic.

Action:
It works in the similar way as thiazide diuretics.
Uses:
It is used as diuretic.

Chlorthalidone

It is a thiazide like diuretic sulfonamide.

Action:
It causes inhibition of the transport of the sodium ions across the renal tubular epithelium in the ascending limb of the loop of Henle.

Pharmacokinetics:
It has long duration of action, so given once per day..

Uses:
It is used as a diuretic in the treatment of hypertension.

Dichlorophenamide

It is a diuretic sulfonamide.

Action:
It is a carbonic anhydrase inhibitor.
Uses:
It is used as diuretic.Its most important use is in the treatment of glaucoma.

Methazolamide

It is a diuretic sulfonamide.

Action:
It is a strong and effective inhibitor of Carbonic anhydrase.
Uses:
It is used as diuretic and in the treatment of glaucoma.

Ethoxzolamide

It is a diuretic sulfonamide.

Action:
It binds to and causes inhibition of the enzyme carbonic anhydrase I.
Uses:
It is used as diuretic. It is also used in glaucoma.

Bumetanide

It belongs to the class of diuretic sulfonamide. It is a metanilamide derivative.


Action:
It interferes with renal cAMP and/or results in the inhibition of the sodium/potassium ATPase pump. It causes dilation of blood vessels in the kidneys and thus increases renal blood flow.

Pharmacokinetics:
Its half life is 1-1.5 hour. Its onset of action is 30 minutes to 90 minutes and duration of action is 4-6 hours.

Uses:
It is used as diuretic and can also be used in the treatment of edema associated with congestive heart failure. It is also used for Hepatic Cirrhosis.

Adverse effects:
Nausea, vomiting, rashes and abdominal pain

Interaction:
Furosemide and bumetanide weakly inhibit carbonic anhydrase.

Benzolamide

It is a diuretic sulfonamide and is an orphan drug.

It is similar to acetazolamide.

Action:
It is a carbonic anhydrase inhibitor.

Uses:
It is used as diuretic and can be used in the cases of respiratory failure.