Tuesday, March 22, 2011

Acetazolamide

It is a diuretic sulfonamide.

Action:
It is a carbonic anhydrase inhibitor.

Uses:
It is used in the treatment of epileptic seizures, glaucoma, edema due to congestive heart failure and diuretic.

Sulfaphenazole

(It is in experimental stages.)

It is a long acting sulfonamide antibacterial.

Action:
It specifically inhibits CYP2C9 i.e an important cytochrome P450 enzyme important in the oxidation of endogenous compounds.

Sulfametopyrazine

(It is now withdrawn)
It is a long acting sulfonamide.

Action:
It competitively inhibits the bacterial enzyme dihydropteroate synthetase.

Uses:
It is used for Urinary tract infections, Respiratory tract infections and malaria.

Sulfamethoxy-pyridazine

It is a long acting sulfonamide.

Uses:
It is used to treat Urinary Tract Infections, Pneumonia and bronchitis.

Sulfadoxine

Sulfadoxine is an intermediate to long acting sulfonamide.

Uses:
It is generally used in combination with other drugs

Sulfacetamide

It is an intermediate acting sulfonamide and is available in the salt form alongwith sodium.

Mechanism of Action:
It competitively inhibits the bacterial enzyme para-aminobenzoic acid resulting in the inhibition of the synthesis of the folic acid.

Uses:
It is used in the treatment of skin infections and orally it is useful in the treatment of Urinary tract infections.

Monday, March 21, 2011

Sulfisomidine

It is also known as sulfasomidine and it is a short acting sulfonamide.

It is similar to sulfadimidine.