Amikacin

It is an aminoglycoside antibiotic derived from Kanamycin A.

Action:
It binds to 30S ribosome of susceptible organism resulting in the inhibition of bacterial protein synthesis.

Uses:
It is used for the treatment of severe infections caused by Gram Negative Organisms including E. coli and Pseudomonas species.

Verdamicin

It is an aminoglycoside derived from "Micromonospora" bacteria.

It is similar to gentamicin.

Gentamicin

It is an aminoglycoside antibiotic derived from "Micromonospora" bacteria.

Mechanism of Action:
It binds irreversibly to 30S-subunit proteins and 16S rRNA resulting in the production of nonfunctional peptide.

Uses:
It is used to treat infections caused by E. coli and proteus species.

Spectinomycin

It is an aminoglycoside antibiotic derived from "Streptomyces" bacteria.

Mechanism of Action:
It acts on 30S ribosomal subunit resulting in the inhibition of the protein synthesis in the bacterial cell wall.

Uses:
It is used for the treatment of gonorrhea.

Hygromycin B

It is an aminoglycoside antibiotic derived from "Streptomyces" bacteria.

Action:
It inhibits polypeptide synthesis.

Kanamycin

It is an aminoglycoside derived from "Streptomyces" bacteria.

Action:
It binds irreversibly to 30S ribosomal subunit proteins and 16S rRNA. This results in the non-functional peptides.

Uses:It is used for the treatment of infections caused by E.coli and proteus species.

Neomycin

It is an aminoglycoside derived from "Streptomyces" bacteria.

Action:
It binds to 30S ribosomal subunit and resulting in the production of non-functional peptide.

Uses:
It is used topically for the treatment of superficial eye infections and may be used orally for the treatment of hepatic encephalopathy.