Monday, March 21, 2011

Physostigmine

Physostigmine is avalaible in the salt form of Physostigmine hydrochloride and Physostigmine Salicylate. It is a parasympathomimetic and is a reversible cholinesterase inhibitor.

Uses:
It is used in the treatment of Alzheimer's disease. It is also used for the treatment of glaucoma.

Memantine

Mematine is available in the salt form as a compound of Memantine hydrochloride.

Mechanism of Action:
Memantine is an N-methyl-D-Aspartate (NMDA) receptor antagonist.

Uses:
It is used in the management of Alzheimer's disease.

Galantamine

It is available in the salt form of Galantamine Hydrobromide.

Action:
It is an acetylcholinesterase inhibitor working additionally on acetylcholine receptor in this way it not only inhibits breakdown of acetylcholine but also results in its distribution.

Uses:
It is used in the treatment of mild to moderate Alzheimer's disease and various memory impairments.

Donepezil

It is available in the salt form of Donepezil Hydrochloride.

Mechanism of Action:
It is a centrally acting reversible acetylcholinesterase inhibitor resulting in an increased action of acetylcholine by inhibiting its break down by the cholinesterase enzyme.

Uses:
It is used in the treatment of Alzheimer's disease.

Trihexyphenidyl

Action:
It belongs to Anti-Muscarinic Class.

Uses:It is used in the symptomatic treatment of Parkinson's disease.

Tolcapone

Action:
It caused inhibition of the enzyme Catechol-O-Methyl-Transferase (COMT) which results in the degradation of the dopamine.

Uses:
Tolcapone is used alongwith levodopa in the treatment of Parkinson's disease.

Selegiline

Mechanism of Action:
It selectively inhibits Monoamine Oxidase-B which causes the metabolism of dopamine and phenylethylamine.

Action:
It enhances and prolongs the Anti-Parkinsonian effects of levodopa but alone it is not of much benefit.

Uses:
It is used in the early stages of Parkinson's disease. It can also be used in Senile Dementia and depression.