Thursday, March 3, 2011

Third Professional, First semester, Pharmaceutical Chemistry

PHARMACEUTICAL CHEMISTRY-III (Instrumentation-I)
(Theory)


Cr. Hr. 03

Note:- The topics will be taught with special reference to their Pharmaceutical Applications.

Theory, Instrumentation and Pharmaceutical Applications of the following Spectroscopic Methods

1. Atomic Absorption and Emission Spectroscopy.

2. Molecular fluorescence spectroscopy.

3. Flame Photometry.

4. I.R. Spectroscopy.

5. Mass Spectroscopy.

6. NMR Spectroscopy.

7. UV/Visible Spectroscopy.

PHARMACEUTICAL CHEMISTRY-III (Instrumentation-I)
(Laboratory)

Cr. Hr. 01

NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the requirements, e.g. Determination of the Purity and Composition of the unknown drugs by using at least each of the above techniques.

Recommended Books

1. Lough W J, High Performance Liquid Chromatography, Blacki Academic Press, New York, 1996.
2. William Kemp,Organic Spectroscopy, Ellsi Horwood, London, 1990.
3. M Aminuddin & Javed Iqbal, Theory and Practice of Chromatography, University Grants Commission, Islamabad-Pakistan (2000).
4. A H Beckett and J B Stennlake, Practical Pharmaceutical Chemistry, Part I and II, the Aulton Press, London.
5. A M Knevel and F E Digangi, Jenkins’s quantitative Pharmaceutical Chemistry, McGraw-Hill Book Company, New York.
6. Braithwaite and F J Smith, Chromatographic Methods, Chapman and Hall, London.
7. E Heftmann, Chromatography, Von Nostrond Reinheld Co, New York, 1975.
8. Pryde and M J Gilbert, Applications of High Performance Liquid Chromatography, Chapman & Hall, London, 1979.
9. E Stahl, Thin Layer Chromatography, Springer-Verlag, Berlin, 1969.
10. R Hamilton, Introduction to HPLC, P A Sewell, Chapman & Hall, London, 1982

Third Professional, First semester, Pharmacognosy

PHARMACOGNOSY-III
(Theory)

Cr. Hr. 03


1. SEPARATION AND ISOLATION OF PLANT CONSTITUTIONS: An introduction to chromatography and chromatographic techniques e.g. Adsorption Chromatography and Partition Chromatography.

2. CARBOHYDRATES: Introduction of carbohydrate.

(a) Sucrose and Sucrose containing drugs: Sucrose, Dextrose, Liquid glucose, Fructose, Lactose, Xylose, Caramel, Honey, Starch, Inulin, Dextrine etc.

(b) Cellulose and Cellulose Derivatives: Purified cotton, Powdered cellulose, Microcrystalline cellulose, Methyl cellulose, Sodium Carboxy-methyl cellulose.

(c) Gums and Mucilages: Tragacenth, Acacia, Sodium Alginate, Agar, Pectin.

3. GLYCOSIDES: Introduction, classification, chemistry and medicinal uses of:

(a) Cardioactive glycosides: Digitalis, Strophanthus and white squill.

(b) Anthroquinone glycosides: Cascara, Aloe, Rhubarb, Cochineal and Senna.

(c) Saponin glycosides: Glycyrrhiza, Sarsaparilla.

(d) Cyanophore glycosides: Wild cherry.

(e) Isothiocyanate glycosides: Black Mustard.

(f) Lactone glycosides: Cantharide.

(g) Aldehyde glycosides: Vanilla.

(h) Miscellaneous glycosides: Gentian,. Quassia, Dioscorea.

4. TANNINS: Introduction, classification, properties and chemical identity tests of Tannins and Tannin containing compounds. Detailed study of Hammamelis, Catechu and Nut Galls.

5. LIPIDS: Introduction. Detailed study of:

(a) Fixed Oils: Castor oil, cotton seed oil, olive oil, peanut oil, sun flower oil, corn oil, coconut oil, Almond oil, Linseed oil, Mustard oil, Sesame oil and soybean oil.

(b) Fats and Related Compounds: Theobroma oil and Lenolin.

(c) Waxes: Bees wax, carnauba wax, spermaceti and Jojoba oil.

PHARMACOGNOSY-III
(Laboratory)

Cr. Hr. 01

NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g. Extraction of the active constituents of crude drugs and chemical tests for their identification.

Recommended Books

1. V E Tyler, L R Brady and J E Robbers, Pharmacognosy, 9th Ed.,
2. G E Trease and W C Evans, Pharmacognosy, W B Saunders, Philadelphia, Toronto,
3. K Usmanghani, Topics in Pharmacognosy, University Grants Commission .
4. T E Wellis, Text book of Pharmacognosy, CBS Publishers & Distributors
5. Varro E Taylor, Pharmacognosy, Lee Febiger Philadelphia, 9th Ed.
6. Mohammad Ali, Introduction to Pharmacognosy, CBS Publishers & Distributors,
7. K Usmanghani, Chemical Pharmacognosy, University Grants Commission,
8. Youngkin H W, Text Book of Pharmacognosy. The Blakiston Co. Toronto, 6th Ed.,

Third Professional, First Semester,Pharmacology

 PHARMACOLOGY & THERAPEUTICS (Systemic Pharmacology)
(Theory)


Cr. Hr. 03

1. DRUGS ACTING ON CENTRAL NERVOUS SYSTEM

(a) CNS – Depressants: Hypnotic & Sedatives and Analgesics (Narcotic Analgesics and opioid antagonists, Analgesic, Antipyretic and Anti-inflammatory drugs [NSAID] including

Disease-modifying antirheumatic drugs and Drug treatment of Gout)

(b) CNS – Stimulants: Cerebral Stimulants, Medullary stimulants, Spinal Cord Stimulants, Antidepressants, Psychotomimetic or Hallucinogenics, Psychotherapeutic Agents (Anxiolytics and Antipsychotics), Drug treatment of Epilepsy and Drug treatment of Parkinsonism and other movement disorders.

2. ANAESTHETICS

(a) Anaesthesia and its clinical importance.

(b) General Anaesthesia, Mechanism of action and its application.

(c) General Anaesthetics.

(d) Local Anaesthetics.

(e) Spinal Anaesthesia and drug used.

(f) Techniques of Local Anaesthesia.

Note:

1. Only an introduction will be given of the banned and obsolete drug products.

2. While dealing with Pharmacology stress should be laid to the group actions of related drugs and only important differences should be discussed of the individual drugs placed in same group.

3. Newly introducted drugs should be included in the syllabus while drugs with no clinical and therapeutic values ought to be excluded from syllabus at any time.

4. The prototype drugs in each group from the latest edition of the recommended books.

PHARMACOLOGY & THERAPEUTICS (Systemic Pharmacology)
(Laboratory)

Cr. Hr. 01

NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g. To study the convulsant effects of strychnine and picrotoxin in frogs and to determine the site of action. To identify the unknown (convulsant) drug and determine its site of action. To study the effects of Adrenaline on Human Eyes. To study the effects of Pilocarpine on Human Eyes. To study the effect of Homatropine on Human Eyes. To identify and observe the effects of unknown drugs on Human Eyes. To study the effects of local anaesthetic drugs on human and the nerve plexus of frog.

Recommended Books

1. Goodman Gillman, Pharmacological basis of therapeutics.
2. Winguard and Brody, Human Pharmacology, Mosby Year Book, Boston, 1991.
3. James M Ritter and Lionel De Levis, A Text book of Clinical Pharmacology, Oxford University Press, New York, 1995.
4. R S Satorkar and S D Bhandarkar, Pharmacology and Pharmacotherapeutics,
5. J D Tripathy, Essential of Medical Pharmacology, Japees Brother, New Delhi,
6. D R Laurance, Clinical Pharmacology, ELBS, London, 6th Ed., 1987.
7. Katzung, B G, Basic and Clinical Pharmacology,
8. Lipponcott, Pharmacology, Lippincot William & Willkin, USA, 2001.
9. Manuchair Edabi, Pharmacology, Little Brown & Company, London, 1993.
10. Prof Dr A Qayum, Fundamentals of Experimental Pharmacology.
11. Bertram G K, Basic and Clinical Pharmacology
12. William F Ganong, W F, Review of Medical physiology

Third Professional, First Semester, Pathology

PATHOLOGY
(Theory)

Cr. Hr. 03
1. SCOPE OF PATHOLOGY and; CONCEPT OF DISEASES:

2. DEFINITION AND TERMINOLOGY: Ischemia, Hypoxia, Necrosis, Infarction, Atrophy, Hypertrophy, Hyperplasia, Metaplasia, Aplasia, Anaplasia.

3. RESPONSE OF BODY TO INJURY AND INFECTION: Acuate inflammation, Chronic inflammation, Immunity, Allergy, Hyper Sensitivity.

4. SPECIFIC: Ulcer (Peptic, Doudenal), Hypertension, Leukemia or Blood Cancer (Malignant Carcinoma, Sarcoma & Lymphomas), Diagnosis and treatment of Cancer in general, fate, survival and prognosis with tumors.

PATHOLOGY
(Laboratory)

 Cr. Hr. 01

Study of Pathological Slides of various Pathological Conditions

Acute inflammation, Chronic inflammation, Chronic specific inflammation, Different types of Degeneration, Thrombosis, Embolism, Infarction, Necrosis, Gangrene, Hyperplasia, Metaplasia, Pigmentation, Calcification, CVC, Papilloma, Adenoma, Chondroma, Fibroma, Leomyoma, Neofibroma, Sq. Cell Carcinoma, Basal Cell Carcinoma, Transitional Cell Carcinoma, Adenocarcinoma, Fibrocarcinoma, Rhadomyosarcoma, Leomyosarcoma, Lymphosarcoma, Liposarcoma, Reticular Cell Sarcoma, Hodgkins disease, Breast Carcinoma, Osteogenic Sarcoma, Osteoclastoma.

Examiantion of different body fluids in various Pathological Conditions

Urine complete Examination, stool Examination, Blood Complete Examination, Semen Examination, Cerebrospinal Fluid Examination, Pericardial fluid examination, Pleural Fluid Examination, Ascitic Fluid Examination, Blood Sugar, Blood Urea, Blood Choleterol etc.

Tests for various Specimens of Clinical Importance

Techniques of Clinical Blood Examination for various disases, Gastric Analysis, Tests for liver function test, Renal function test, Tests for endocrine abnormalities, Biopsies and cytologic techniques.

Recommended Books
1. Kumar Cotran Robins, Basic Pathology, 6th Ed., W B Saunders Company, Philadelphia (1992).
2. Walters and Israel, General Pathology, Churchill Livingstone, London (1998).
3. Peter S Macfarlane, Robin Reid, Robin Collander, Pathology Illustrated, Churchill Livingstone, London (1998).
4. Robbins Pathology, W B Saunders Co, London, 2nd Ed., 1962.
5. Walter G B, General Pathology, Churchill Livingstone, New York, 1996.

Wednesday, March 2, 2011

Second Professional, Second Semester, Islamiyat

ISLAMIYAT
(Theory)


Cr. Hr. 03

As per syllabi of B.A/B.Sc. classes, approved by the respective University

Second Professional, Second Semester, Microbiology

PHARMACEUTICAL MICROBIOLOGY-II
(Theory)

Cr. Hr. 03


Note:- The topics will be taught with special reference to their Pharmaceutical Applications.

2. INDUSTRIAL MICROBIOLOGY: Introduction to Sterilization/Disinfection. Fermentation. Pharmaceutical products produced by fermentation process (Penicillins, Cepalosporins, Gentamycin, Erythromycin, Tetracyclines, Rifamycin, Griseofulvin)

3. IMMUNOLOGY: Introduction, Types of Imunity: Specific and nonspecific (Cellular basis of Immune response. Immunity, autoimmunity, tolerance. Antigen. Antibodies). Antigen-Antibody reactions and their clinical and diagnostic applications. Hypersensitivity and allergy. Drug allergy mechanism. Vaccination: Introduction and aims. Types of Vaccines. Current vaccine practices.

4. FACTORY AND HOSPITAL HYGIENE AND GOOD MANUFACTURING PRACTICE: Introduction, Control of Microbial contamination during manufacture, Mnaufacture of Sterile products, A Guide to Current Good Pharmaceutical Manufacturing Practices.
PHARMACEUTICAL MICROBIOLOGY-II
(LABORATORY)

Cr. Hr. 01

NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g. Sterilization of Glassware and pharmaceutical products by various methods. Microbiological assays of: Antibiotics and vitamins.

Recommended Books

1. Jawetiz, Medical Microbiology and Immunology, 5th Ed., Churchill Livingstone, London, 1998.
2. W B Hugo & A D Russell, Pharmaceutical Microbiology, Black Well Science Ltd, London, 6th Ed., 1998.
3. Lippincot, Microbiology by lipponcott, William & Willkin, USA, 2001.
4. Alcamo, Introduction to Microbiology, John Bartlett Publishers, 6th Ed., 2003.
5. Collin and Lynes, Microbiological Methods, Vutterworth Heineman, Oxford, 1995.
6. M Mekallee, Microbiology: Essentials and Application, McGraw-Hill Inc, 2nd Ed.
7. Singleton and Sainsbury, Dictionary of Microbiology and Molecular biology, John Willey & Sons, New York, 2000.
8. Pelczar, Microbiology, McGraw-Hill Inc, 1996.
9. Prescott, Harley, Microbiology, 2nd Ed., Klein Wm C Brown Publishers, 2001.

Second Professional, Second Semester, Pharmacognosy

PHARMACOGNOSY-II
(Theory)

Cr. Hr. 03


1. ALLERGENS AND ALLERGENIC PREPARATION: Introduction, case history, skin test, treatment off allergy, inhalant, ingestant, injectant, contactant, infectant and infestant allergens. Mechanism of allergy.

2. ENZYMES: Enzymes obtained from plant source. (Phytoenzymes). Papain Bromelain and Malt Extract. Enzymes obtained from Animal source. Rennin pepsin, Pancreatin and Pancrealipase.

3. POISONOUS PLANTS: General introduction of poisonous plants with special reference to Pakistan.

4. PESTICIDES: Introduction. Methods of controlling pests with special reference to natural methods.
PHARMACOGNOSY-II
(Laboratory)

 Cr. Hr. 01

NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g. Microscopic examination of powders and sections of plant drugs. A Study Tour will be an integral part of the syllabus and will be arranged at the end of the session for collection of medicinal plants from various hilly areas of the country.

Recommended Books

1. V E Tyler, L R Brady and J E Robbers, Pharmacognosy, 9th Ed., Lea and Febiger, Philadelphia, 1988.
2. G E Trease and W C Evans, Pharmacognosy, W B Saunders, Philadelphia, Toronto, 2002.
3. K Usmanghani, Topics in Pharmacognosy, University Grants Commission Monograph Series, Islamabad, pp74, 1985.
4. T E Wellis, Text book of Pharmacognosy, CBS Publishers & Distributors, New Delhi, 1986.
5. Varro E Taylor, Pharmacognosy, Lee Febiger Philadelphia, 9th Ed.
6. Mohammad Ali, Introduction to Pharmacognosy, CBS Publishers & Distributors, New Delhi, 1986.
7. K Usmanghani, Chemical Pharmacognosy, University Grants Commission, Islamabad, 1985.
8. Youngkin H W, Text Book of Pharmacognosy, The Blakiston Co, Toronto, 6th Ed., 1948.