First Professional; First Semester, Pharmaceutics

PHARMACEUTICS-I (PHYSICAL PHARMACY-I)
(Theory)

Cr. Hr. 03

1. PHARMACY ORIENTATION:
Introduction and orientation to the Professional of pharmacy in relation to Hospital Pharmacy, Retail pharmacy, Industrial pharmacy, Forensic pharmacy, Pharmaceutical education and research etc.

2. HISTORY AND LITERATURE OF PHARMACY:
(a) A survey of the history of pharmacy through ancient, Greek and Arab periods with special reference to contribution of Muslim scientists to pharmacy and allied sciences.

(b) An introduction of various official books.

3. PHYSIOCHEMICAL PROCESSES:
(a) Precipitation: Process of precipitation and its applications in Pharmacy.
(b) Crystallization: Types of crystals, Mechanism and methods of crystallization and its applications in Pharmacy.
(c) Distillation: Simple, fractional, steam distillation, vacuum distillation, destructive distillation and their applications in Pharmacy.
(d) Miscellaneous Processes: Efflorescence, deliquescence, lyophillization, elutriation, exsiccation, ignition, sublimation, fusion, calcination, adsorption, decantation, evaporation, vaporization, centrifugation, dessication, levigation and trituration.

4. PHYSICO-CHEMICAL PRINCIPLES:

(a) Solutions: Introduction, types, concentration expressions, ideal and real solution, colligative properties, their mathematical derivations and applications in pharmacy, molecular weight determinations, distribution co-efficient and its applications in pharmacy.

(b) Solubilization: Solubility, factors affecting solubility, surfactants, their properties and types. Micelles, their formulation and types.

(c) Ionization, pH, pH indicators, pka, buffers, buffer’s equation, isotonic solutions and their applications in pharmacy.

(d) Hydrolysis, types and protection of drugs against hydrolysis.

(e) Micromeritics: Particle size and shapes, distribution of particles methods of determination of particle size and importance of particle size in Pharmacy.

PHARMACEUTICS-I (PHYSICAL PHARMACY-I)
(Laboratory)

Cr. Hr. 01

NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g. Experiments to demonstrate some of the physicochemical processes like simple distillation, steam distillation, crystallization and dialysis. Determination of particle size. Preparation of buffer solutions and isotonic solutions.

Recommended Books

1. Martin, Physical Pharmacy, B I Waverly PVT, Delhi, 4th Ed., 1994.
2. Cooper and Gunns, Tutorial Pharmacy, CBS Publishers and Distributors, New Delhi,
3. Bentley’s Pharmaceutics, All India Traveler Book Seller, New Delhi, 1996.
4. Martin P, Bustamante P and Chun, Physical and Chemical Principles of Pharmaceutical Science, AHC, 4th Ed., (1999), New York.
5. Martin AMN, Banker G S and Chun AHC Advances in Pharmaceutical Sciences.
6. Mill C C Casson, N, Rheology of dispress systems. Pergamon Press, New York, 1975.