Fifth Professional, Second Semester, Pharmaceutical Chemistry

PHARMACEUTICAL CHEMISTRY-VI (Medicinal Chemistry-VI)
(Theory)


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Note:- The topics will be taught with special reference to their Pharmaceutical Applications.

1. GENERAL PROPERTIES, CHEMISTRY, BIOLOGICAL ACTION, STRUCTURE ACTIVITY RELATIONSHIP AND THERAPEUTIC APPLICATIONS OF THE FOLLOWING:

(a) Anti-septics: Phenols and related compounds, Halogens and Halogen compounds, Aromatic acid and esters, Dyes, Nitrofuran derivatives, Formaldehyde and its derivatives, Mercurochrome and Thiomersal.

(b) Sulphonamides: Prontosil, sulphanilamide, Sulphapyridine, sulphadimidine, Sulfamethoxazole, Sulfadiazine and Sulfafurazole.

(c) Antimalarials: 4-Aminoquinolines, 8-Aminoquinolines, 9-Amino acridines, Biguanides, Pyrimidine analogues, Mefloquine and Cinchoha alkaloids.

(d) Anthelmintics: Phenols and related compounds, Piperazine derivatives, Thiabendazole, Mebendazole and Pyrantal.

(e) Diuretics: Mercaptomerin, Meralluride, Thiazides, Sprironolactone, Theophylline, Furosemide, Acetazolamiode, Ethacrynic acid and Triameterene.

(f) Anti-tubercular Drugs: Ethambutol, Isonicotinic acid, Hydrazid, Rifampacin, Thioguanine, Pyrazinamide, cycloserine, Ethunamide, Cytarabine, 5- Flourouracil and Dacarbazine.

(g) Antiviral Drugs: Acyclovir, Tromantadine Hydrochloride and Ribavirin.

(h) Immunosuppressant Agents: Azathioprine and Cyclosporin.

2. ANTIBIOTICS:

Penicillins, Cephalosporins, Streptomycin, Chloramphenicol, Tetracyclines, Kanamycin and Erythromycin.

PHARMACEUTICAL CHEMISTRY-VI (Medicinal Chemistry-VI)
(Laboratory)

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NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g.

1. Assay of the Drugs like Sulpha drugs, Aspirin, Paracetamol, Benzyl Penicillin.

2. Inorganic Preparations.

Recommended Books

1. Martin and Cook, Remington Practice of Pharmaceutical Science,
2. Foye W O, Principles of Medicinal Chemistry, Verghese Publising House,
3. Tyagi, Text Book of Synthetic Drugs, Anmol Publications, Delhi, 1990.
4. Alferd Burger, Medicinal Chemistry, Jhon Willey & Sons, New York,
5. Block, Roche, Soine and Wilson, Inorganic and Medicinal Pharmaceutical Chemistry, Verghese Publishing House, Bombay, 1986.
6. Block, Roche, Soine and Wilson. Inorganic and Medicinal Pharmaceutical Chemistry, Lee & Febiger, Philadelphia, USA, 1983.