Fifth Professional, First Semester, Pharmaceutical Chemistry

PHARMACEUTICAL CHEMISTRY-V (Medicinal Chemistry-I)
(Theory)

Cr. Hr. 03

Note: The topics will be taught with special reference to their Pharmaceutical Applications.

1. INTRODUCTION TO MEDICINAL CHEMISTRY: Chemical constitution and biological activity: (Receptor, Theory, Structure Activity Relationships (SAR) and Drug Metabolism).

2. CLASSIFICATION OF SYNTHETIC DRUGS: Drug Design and recent approaches to the synthesis of drugs (a brief concept of methods and reactions of synthesis of various drugs).

3. GENERAL PROPERTIES, CHEMISTRY (General methods of determination, the structure & isolation from natural source), BIOLOGICAL ACTION, STRUCTURE ACTIVITY RELATIONSHIP AND THERAPEUTIC APPLICATIONS OF THE FOLLOWING:

e) Anaesthetics: Local anaesthetics (Procaine, Lignocaine, Eucaine, Cocaine and Benzocaine), General anaesthetics (Cyclopropane, Halothane, Nitrous oxide, Chloroform, Thiopental Sodium, Ketamine, Methohexital, Thioamylal Sodium, Fantanyl Citrate, Tribromo ethanol).

f) Analgesics and Antipyretics: Paracetamol, Salicylic acid analogues, Quinolines derivatives, Pyrazolone and Pyrazolodiones, Narylanthranilic acids, Aryl and heteroaryl acetic acid derivatives.

d) Sedatives and Hypnotics: Benzodiazepines, Barbiturates, Paraldehyde, Glutethimide, Chloral hydrate, and alcohols.

a) Vitamins: Water Soluble Vitamins (B1, B2, B6, B12, Folic acid, Nicotinic acid, Biotin, Pantothenic acid and Ascorbic acid) Fat Soluble Vitamins (A, D, E, and K).

b) Hormones: Steroidal Hormones (Testosterone, Progesterone, Estrogen, Aldosteron and Cortisol), Proteinous Hormones (Insulin, Glucagon, Oxytocin and Vassopressin).

c) Anti-neoplastic Agents: Tamoxifen, Fluorouracil, Mercapturine, Methotrexate and Vincristine.


PHARMACEUTICAL CHEMISTRY-V (Medicinal Chemistry-I)
(Laboratory)

Cr. Hr. 01

NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g.

1. Estimation of functional groups; Carboxylic, Hydroxy, Amino and Nitro groups; Determination of Molecular weights of Organic Compounds.

2. Synthesis of Paracetamol, Salicylic Acid, Methyl salicylate, Azobenzene, Benzoic Acid, 5-Hydroxy-1,3-benzoxazol-2-one, Aspirin, P-nitrosophenol, 3-nitrophthalic acid, o-Chloro-benzoic acid.

Recommended Books

1. Martin and Cook, Remington Practice of Pharmaceutical Science, Mack Publishing Company, USA, 2001
2. Foye W O, Principles of Medicinal Chemistry, Verghese Publising House, Bomby, 1995.
3. Tyagi, Text Book of Synthetic Drugs, Anmol Publications, Delhi, 1990. 4. Alferd Burger, Medicinal Chemistry, Jhon Willey & Sons, New York, 1996.
4. Block, Roche, Soine and Wilson, Inorganic and Medicinal Pharmaceutical Chemistry, Verghese Publishing House, Bombay, 1986.
5. Block, Roche, Soine and Wilson. Inorganic and Medicinal Pharmaceutical Chemistry, Lee & Febiger, Philadelphia, USA, 1983.