It is a plant alkaloid derived from the roots of plant Rauwolfia Serpentina.
Mechanism of action:
Reserpine works to prevent neuronal and chromaffin granule transporters by Mg2+/ATP dependent transport mechanism.
As a consequence accumulation of catecholamine transmitters by adrenergic transmitter vesicles is prevented resulting in great depletion of transmitters in both central and peripheral neurons that can remain for days to weeks. Monoamine oxidase has the ability of degrading norepinephrine in the cytoplasm.