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1. GENERAL INTRODUCTION AND BASIC BIOCHEMICAL PRINCIPLES
Role of pharmaceutical biochemistry in the health profession.
Nature of biochemical reactions.
2. BASIC CHEMISTRY OF BIOMOLECULES (Nature, Classification etc.)
(a) Carbohydrates: Chemistry, Classification, Reactions of Carbohydrates, Optical activity, Biological and pharmaceutical importance of carbohydrates.
(b) Lipids: Chemistry of Fatty acids and Lipids, Classification (Saponifiable and non-saponifiable lipids, Simple, Complex and 77 derived lipids), Reactions of Fatty acids and other Lipids, Essential fatty acids, Biological and pharmaceutical importance of lipids.
(c) Proteins and Amino acids: Chemistry, Classification of proteins and amino acids, Reactions of proteins and amino acids, Organizational levels, Macromolecular nature of proteins, Biological and pharmaceutical importance of proteins and amino acids.
(d) Nucleic acids: Chemistry, Types (DNA, RNA, mRNA, tRNA, rRNA), Purine and Pyrimidine bases, Nucelosides, Nucelotides, Structures of nucleic acids, Biological and pharmaceutical importance of nucleic acids.
(e) Vitamins: Chemistry, Classification (Fat-soluble and water-soluble vitamins), Biological and pharmaceutical importance of vitamins.
(f) Hormones: Chemistry, Classification (Proteinous and nonproteinous hormones, amino acid derivatives, steroids), Biological and pharmaceutical importance of hormones.
(g) Enzymes: Chemistry, Classification, Mode of action, Kinetics (Michaelis Menten Equation and some modifications), Inhibition, Activation, Specificity, Allosteric enzymes, Factors affecting the rate of an enzyme-catalyzed reaction, Biological and pharmaceutical
importance, Mechanism of action of some important enzymes (Chymotrypsin, Ribonuclease).
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NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g. Qualitative analysis of: Carbohydrates, Amino acids, Peptides and Proteins, Lipids and Sterols (Cholesterol) Bile salts and billirubin, Blood analysis – Sugar, Uric acid, Billirubin, Cholesterol and Creatinine.
1. M N Chaterjea, Medical Biochemistry, Jaypee Brothers Medical Publishers, New Delhi, 2003.
2. Roberk Murray, Daryl K, Granner, Peter A Mayes, Victor W Rodwell Harper’s Biochemistry, Appleton and Lange, Lange Medical Publications, NewYork, 2000.
3. Albert L Lehninger Principles of Biochemistry, CBS Publisher, Delhi, 1993.
4. Lubert Stryer, Biochemistry, W H Freeman and Company, 2002.
5. Pamela C Champe, Richard A Harvey, Illustrated Biochemistry, J Lippincot Company, 1994.
6. M Rafiq, Biochemistry, The Carvan Book House, Lahore, 1st Ed.
7. Montogomary, Clinical Chemistry, The C V Mosby Company, 5th Ed.
8. Student's Companion to Stryer's Biochemistry by Lubert Stryer