Tuesday, March 22, 2011


It belongs to the class of diuretic sulfonamide. It is a metanilamide derivative.

It interferes with renal cAMP and/or results in the inhibition of the sodium/potassium ATPase pump. It causes dilation of blood vessels in the kidneys and thus increases renal blood flow.

Its half life is 1-1.5 hour. Its onset of action is 30 minutes to 90 minutes and duration of action is 4-6 hours.

It is used as diuretic and can also be used in the treatment of edema associated with congestive heart failure. It is also used for Hepatic Cirrhosis.

Adverse effects:
Nausea, vomiting, rashes and abdominal pain

Furosemide and bumetanide weakly inhibit carbonic anhydrase.
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