Saturday, October 11, 2008

Classification of Aminoglycosides

Aminoglycosides include:
1. Those that are derived from the genus of bacteria namely "Streptomyces". These aminoglycoside antibiotics end with "-mycin" and include:
a. Streptomycin ·
b. Neomycinc.
c. Kanamycin
d. Hygromycin B ·
e. Spectinomycin.

2. Those that are derived from the genus of bacteria namely "Micromonospora". These aminoglycoside antibiotics end with "-micin" and include:
a. Gentamicin
b. Verdamicin

3. Those that are derived from these antibiotics:
a. Arbekacin(1)
b. Framycetin
c. Amikacin
d. Paromomycin
e. Ribostamycin
f. Dibekacin
g. Tobramycin
h. Netilmicin
i. Sisomicin
j. Isepamicin(2)
k. Habekacin (N. Tanaka et al.)

Further reading:
Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery by Dey P. Arya.

References:
(1) Arti Kapil, Rashi Bali, B. K. Das, In vitro susceptibility of nosocomial isolates against a new aminoglycoside isepamicin. Indian Journal of Medical Research, Feb 2001.

(2) M. Inoue, M. Nonoyama , R. Okamoto, T. Ida. Antimicrobial activity of arbekacin, a new aminoglycoside antibiotic, against methicillin-resistant Staphylococcus aureus. Drugs under experimental and clinical research, 1994, volume 20, number 6, pages 233-239.

N. Tanaka, K. Matsunaga, A. Hirata, Y. Matsuhisa and T. Nishimura. Mechanism of action of habekacin, a novel amino acid-containing aminoglycoside antibiotic. Antimicrob Agents Chemother. 1983 November; 24(5): Pages 797–802.

Further Reading:
The Goodman and Gilman Manual of Pharmacology and Therapeutics by Laurence Brunton, Donald blumenthal, Iain buxton and Keith Parker

AHFS Drug Information 2008 (Ahfs Drug Information) by American Society of Health-system

Lippincott's Illustrated Reviews: Pharmacology, 4th Edition (Lippincott's Illustrated Reviews Series) by Richard A. Harvey, Pamela C. Champe, Richard Finkel, Luigi Cubeddu and Michelle A. Clarke

Copyright, (c), 2008, http://jeepakistan.blogspot.com
Post a Comment