Saturday, October 11, 2008

Arbekacin

(M. Kurebe et al.) Chemical name of Arbekacin is "1-N[(S)-4-amino-2-hydroxybutyl]-3',4'-dideoxykanamycin B".(Yusuke Tanigawara et al.) It is a derivative of "Dibekacin". (M. Inoue et al.)Arbekacin works good against methicillin resistant staphylococcus aureus (MRSA), which are even resistant to other types of good aminoglycosides. (M. Kurebe et al.)It is less toxic to ear than amikacin and dabekacin.

Dosage and administration:
(Yusuke Tanigawara et al.) Its usual dose for adults is 150-200 mg/day. It is administered IV or IM in divided doses.

Pharmacokinetics:

Elimination:
(Yusuke Tanigawara et al.) It is eliminated in the urine.

References:
M. Inoue, M. Nonoyama , R. Okamoto, T. Ida. Antimicrobial activity of arbekacin, a new aminoglycoside antibiotic, against methicillin-resistant Staphylococcus aureus. Drugs under experimental and clinical research, 1994, volume 20, number 6, pages 233-239.

M. Kurebe, M. Yokota, T. Niizato, F. Kai, T. Yoshida, R. Okamoto, S. Mitsuhashi. Antibacterial activity and ototoxicity in guinea pigs, and nephrotoxicity in rats of arbekacin. Arzneimittelforschung. 1986 Oct; Volume 36(10): Pages 1511-7.

Yusuke Tanigawara, Reiko Sato, Kunihiko Morita, Mitsuo Kaku, Naoki Aikawa, and Kihachiro Shimizu. Population Pharmacokinetics of Arbekacin in Patients Infected with Methicillin-Resistant Staphylococcus aureus. Antimicrobial Agents Chemotherapy. 2006 November; volume 50(11): Pages 3754–3762.

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