Gentamicin

It is an aminoglycoside antibiotic derived from "Micromonospora" bacteria.

Mechanism of Action:
It binds irreversibly to 30S-subunit proteins and 16S rRNA resulting in the production of nonfunctional peptide.

Uses:
It is used to treat infections caused by E. coli and proteus species.

Spectinomycin

It is an aminoglycoside antibiotic derived from "Streptomyces" bacteria.

Mechanism of Action:
It acts on 30S ribosomal subunit resulting in the inhibition of the protein synthesis in the bacterial cell wall.

Uses:
It is used for the treatment of gonorrhea.

Hygromycin B

It is an aminoglycoside antibiotic derived from "Streptomyces" bacteria.

Action:
It inhibits polypeptide synthesis.

Kanamycin

It is an aminoglycoside derived from "Streptomyces" bacteria.

Action:
It binds irreversibly to 30S ribosomal subunit proteins and 16S rRNA. This results in the non-functional peptides.

Uses:It is used for the treatment of infections caused by E.coli and proteus species.

Neomycin

It is an aminoglycoside derived from "Streptomyces" bacteria.

Action:
It binds to 30S ribosomal subunit and resulting in the production of non-functional peptide.

Uses:
It is used topically for the treatment of superficial eye infections and may be used orally for the treatment of hepatic encephalopathy.

Streptomycin

It is an aminoglycosides derived from "Streptomyces" bacteria.

Action:
It causes disruption in the initiation and elongation steps in protein synthesis by binding to the 30S ribosomal subunit of the the susceptible organism.

Mainly active against extracellular tubercle bacilli as it penetrates poorly into cells.

Uses:
It is used for the treatment of tuberculsosis.

Adverse effects:It is ototoxic and nephrotoxic. It may also cause vertigo and hearing loss.

Sulfasalazine

It is an antibacterial sulfonamide.

Uses:
It is used in the treatment of inflammatory bowel disease. It is also used in the treatment of rheumatoid arthritis.