Phthalylsulfathiazole

It is a antibacterial sulfonamide.

Action:
It inhibits the bacterial enzyme dihydropteroate synthetase.

Uses:
It is used to treat intestinal infections.

Sulfapyridine

It is a topical sulfonamide.

Action:
It competitively inhibits the bacterial enzyme dihydropteroate synthetase resulting in the inhibition of folic acid in bacteria.

Uses:
It is an anti-bacterial used to treat pyoderma gangrenosum and dermatitis herpetiformis.

Silver Sulfadiazine

It is a topical sulfonamide.

Action:It acts on the cell wall and cell membrane to produce a bactericidal effect.

Uses:
It is used as an adjunct in the treatment of second and third degree burns.

Mafenide

It is a topical sulfonamide.

Action:
It decreases the bacterial population  and increases the healing around the burns.

Uses:
It is used as an adjunctive treatment for serious burns.

Xipamide

It is a sulfonamide diuretic.

Action:
It decreases sodium reabsorption in the distal convoluted tubule.

Uses:
It is a thiazide like diuretic and is also used in the treatment of hypertension and edema.

Metolazone

It is a sulfonamide diuretic. It is a quinazoline derivative.
Action:
It inhibits sodium reabsorption at cortical diluting site.

Uses:
It is thiazide like diuretic and causes an increase in potassium loss. It is also used in lowering blood pressure.

Mefruside

It is a sulfonamide diuretic.

Uses:
It is a diuretic and is also used for the treatment of hypertension and edema.