Thursday, March 3, 2011

Fourth Professional, Second Semester, Pharmaceutics

PHARMACEUTICS-VII (Hospital Pharmacy-II)
(Theory)


Cr. Hr. 03

1. MANUFACTURING BULK AND STERILE.

2. THE PHARMACY-CENTRAL STERILE SUPPLY ROOM.

3. ASEPTIC DISPENSING

TPN, I/V Admixtures, Cytotoxic Dispensing, Semi-sterile Dispensing (Eye drops, Ear drops) and Hyperailimentation.

4. ROLE OF PHARMACISTS IN SMALL HOSPITALS, NURSING HOMES ETC:

5. PURCHASING, DISTRIBUTION AND CONTROL OF HOSPITAL MEDICINES, MEDICAL & SURGICAL SUPPLIES: Purchasing, Stocking, Stock Control, Inventory Management, Drug Distribution, Relationship between purchasing, Distribution and Clinical

Pharmacy Services.

6. NUCLEAR PHARMACY.

7. THE PHYSICAL PLANT AND ITS EQUIPMENT

8. INVESTIGATIONAL USE OF DRUGS.

9. HEALTH ACCESSORIES.

10. SURGICAL SUPPLIES.

11. INSPECTION OF WARDS WITH REFERENCE TO DRUG STORAGE AND ADMINISTRATION.

12. MANAGEMENT OF ACCIDENT & EMERGENCY PHARMACY (A & E).

13. COMMON KNOWLEDGE OF ABOUT 100 DRUGS REGISTERED BY MINISTRY OF HEALTH, GOVERNMENT OF PAKISTAN.

Recommended Books

1. William Hassan, Hospital Pharmacy, Lee & Febiger, Washington, 5th Ed., 1986.
2. N I Bukhari, Hospital Pharmacy, Aziz Book Depot, Lahore-Pakistan (2000).
3. Martin Stephen, Hospital Pharmacy, Pharmaceutical Press, London, 2003.

Fourth Professional, First Semester, Pharmaceutics

PHARMACEUTICS-XI (Pharmaceutical Quality Management-I)
(Theory)


Cr. Hr. 03

1. SCOPE

(a) An understanding of the testing, quality control programme and methods adopted in a pharmaceutical industry, dosage form control, process control, testing program and methods, physical, chemical and biological tests and specifications, statitical quality control.

(b) General understanding of Total Quality Assurance and measures to adopt Quality Assurance

2. QUALITY CONTROL OF SOLID DOSAGE FORMS:

(a) Physical tests: Hardness, Thickness and Diameter, Friability, Disintegration, Weight Variation.

(b) Chemical tests: Content uniformity, Assay of active ingredients and dissolution tests of Powders, Granules, Tablets and Capsules.

3. QUALITY CONTROL OF SYRUPS AND ELIXIRS:

Viscosity, its determiantion and application in the Quality Control of Pharmaceuticals, Weight per ml and Assay of active ingredients.

4. EVALUATION OF SUSTAINED ACTION PRODUCTS (TABLETS & CAPSULES):

Stability of viability rate during storage and In-vitro & In-vivo evaluation of sustaining action.

5. QUALITY CONTROL OF SUPPOSITORIES Disintegration test, Uniformity of weight, Assay of active ingredients, Liqefaction time test and Breaking test.

6. QUALITY CONTROL OF STERILE PRODUCTS (PARENTERALS) Leaker’s test, Clarity test, Pyrogen test for parenterals and other sterile preparations and Assay for active ingredients.

PHARMACEUTICS-XI (Pharmaceutical Quality Management-I)
(Laboratory)

Cr. Hr. 01

NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g. Assay of various spirits, tinctures, extracts, syrups and elixirs, Assay of Ointments and suppositories, Assay of tablets and capsules, Test for alkalinity of glass, Determiantion of alcohol contents in the Pharmaceutical preparations and Pyrogen test.

Recommended Books

1. A H Beckett and J B Stennlake, Practical Pharmaceutical Chemistry, Part-I and II, The Alton Press, London.
2. M Knevel and F E Digangi, Jenkin’s Quantitative Pharmaceutical Chemistry, McGraw-Hill Book Company, New York.
3. K A Connors, A Text Book of Pharmaceutical Analysis, John — Wiley and Sons, New York.
4. Braithwaite and F J Smith, Chromatographic Methods, Chapman and Hall, London.
5. G D Christian, Analytical Chemistry, John Wiley and Sons, New York.
6. Karamt A Javaid, Pharmaceutical Quality Assurance in Class, Industry and Market, Aziz Publishers, Lahore-Pakistan (1993).
7. Gil Bismuth and Shosh Neumann, Cleaning Validation, A practical approach. CRC Press, LLC, USA, 2003.
8. J T Carstersen and C T Rhodes, Drug Stability: Principles and Practices, 3rd Ed. (revised and expanded), Mercel Dekker, New York. 2000.
9. Sydney H Willig, Good Manufacturing Practices for Pharmaceuticals, Marcel Dekker Publishing.
10. Bryant R, The pharmaceutical Quality Control Hand Book, Aster Publishing Corporation, Eugene, 1989.
11. Braun R E, Introduction to Instrumental Analysis, McGraw-Hill Book Co, NY, 1987.

Fourth Professional, First Semester, Pharmaceutics

PHARMACEUTICS-X (Biopharmaceutics-I)
(Theory)

Cr. Hr. 03

1 DEFINITIONS AND TERMINOLOGY: Biopharmaceutics, Generic Equivalence, Bioavailability, Bioequivalence, Drug Disposition, Therapeutics, Pharmacokinetics, Biotransformation and Therapeutic Equivalents.

2. GASTRO-INTESTINAL ABSORPTION AND PHYSICO-CHEMICAL CONSIDERATIONS. Forces which help in transmembrane movements, pH Partition Theory, Lipid Solubility and Factors affecting Bioavailability.

3. BIOAVAILABILITY STUDIES: Purpose, Relative and Absolute Bioavailability, and Determination of Bioavailability.

4. FACTORS AFFECTING DISSOLUTION IN RESPECT OF BIOAVAILABILITY: Methods of in-vitro and in-vivo determination of rate of dissolution.

5. MULTIPLE DOSAGE REGEMIN.

6. INTRAVENOUS INFUSIONS.

7. BIOPHARMACEUTICAL AND PHARMACOKINETIC ASPECTS IN DEVELOPING A DOSAGE FORM.
PHARMACEUTICS-X (Biopharmaceutics)
(Laboratory)

Cr. Hr. 01

NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g. Blood Sampling Techniques: In Laboratory Animals like dog, rabbits, mice etc. In human beings, In-vitro dissolution studies, Optional dose determination, Measurement of rate of Bioavailability, Determination of relative and absolute bioavailability.

Recommended Books

1. Leon Shargel, Applied Pharmacokinetics and Biopharmaceutics, Appleton & Lange, New York, 4th Ed., 1999.
2. Malcoln Rouland, Thomous N Tozer, Clinical Pharmacokinetics, William & Willkins, London, 1995.
3. Milo Gibaldi, Biopharmaceutics and Clinical Pharmacokinetics, Marchel & Dakker Inc, New York, 1982.
4. Gibbson and Skett, Introduction to Drug Metabolism, Champ & Hall,London, 1986.
5. Robert E Notari, Biopharmaceutics and Clinical Pharmacokinetics, Marchel & Dakker Inc, New York, 1988.
6. Stephen H Curry, Drug disposition and pharmacokinetics, Black Well Scientific Publishing, Oxford, 1977.
7. Avraham Yacobi, Toxicokinetics and New Drug Development, Paramount Press, New York, 1989.
8. Sarfraz Niazi, Text Book of Biopharmaceutics and Clinical Pharmacokinetics. Appleton-Century-Crofts, New York, 1985.
9. P Macheras, C Reppas and J B Dressman, Biopharmaceutics of orally administered drugs, Ellis Horwood Limited, London (1995).
10. Albert P Li, Invitro approaches for evaluation of drug efficacy and toxicity, CRC Press LLC, USA, 2004.
11. Ronald D Schoenwald, Pharmacokinetics in drug discovery and Development, CRC Press, LLC, USA, 2002.

Fourth Professional, First Semester, Pharmaceutics

PHARMACEUTICS-IX (Industrial Pharmacy-I)
(Theory)


Cr. Hr. 03

1. MASS TRANSFER.

2. HEAT TRANSFER.

3. DRYING: Theories of drying, Drying of Solids, Classification of dryers, General Methods, Fluidized Bed systems, Pneumatic systems, Spray dryer, Freeze dying.

4. MIXING: Fundamentals, Mechanisms, Mixing Equipment used in Liquid/Liquid, Liquid/Solid and solid/solid mixing, Communition (size reduction), Reasons for size reduction, Factors affecting size reduction, size analysis, Sieving, Energy Mills (Ball Mill. Endrumer, Edge Rumer, Disintegrant, Colloid Mill, Hammer Mill, Cutter Mill, and Fluid Energy Mill etc.).

5. CLARIFICATION AND FILTERATION: Theory, Filter media, Filter aids, Filter selection and Equipment (Leaf filter, Filter press, Melta filters and Rotary filters).

6. EVAPORATION: General principles of Evaporation, Evaporators and Evaporation under reduced pressure.

7. COMPRESSION AND COMPACTION: The solid-air Interface, Angle of Repose, Flow rates, Mass volume relationship, Density, Heckel Plots, Consolidation, Granulation, Friability, Compression (dry method, wet method, slugging), Physics of Tabletting, tabletting machines and other equipment required, problems involved in tabletting, tablet coating,

Capsulation (Hard and Soft gelatin capsules).

8. SAFETY METHODS IN PHARMACEUTICAL INDUSTRY:

(a) Mechanical, chemical and fire hazards problems.

(b) Inflammable gases and dusts.
PHARMACEUTICS-IX (Industrial Pharmacy-I)
(Laboratory)

Cr. Hr. 01

NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g. Manufacture of Tablets by Wet Granulation Method, by Slugging and by Direct Compression. Coating of Tablets (Sugar Coating, Film coatingand Enteric Coating). Clarification of liquids by various processes. Size Reduction. Homogenization.

Recommended Books

1. Lackman, Theory and Practice of Industrial Pharmacy, Verghese Publishing House, Bombay, 1987.
2. Cooper and Gunn’s, Tutorial Pharmacy, CBS Publishers & Distributors, New Delhi, 1986.
3. Bentley’s Pharmaceutical Text Book, CBS Publishers & Distributors, New Delhi, 1986.
4. Remington’s Pharmaceutical Sciences, Mack Publishing Company, USA, 2001.
5. John Sharp, Good Pharmaceutical Manufacturing Practice, Rational and Compliance.

Fourth Professional, First Semester, Pharmaceutics

PHARMACEUTICS-VIII (Clinical Pharmacy-I)
(Theory)


Cr. Hr. 03

1. GENERAL INTRODUCTION TO CLINICAL PHARMACY: Terminologies, Basic Components and Scope.

2. PATIENT PROFILE:

(a) Patient disease profile.

(b) Taking case History.

(c) Drug Profile of 25 Drugs (Adrenaline, Aminoglycosides, Anti TB Drugs, Antiepileptics, Atropine, Benzodiazepines, Cepahlosporins, Chlorpheniramine, Cimetidine, Digoxin, Dobutamine, Dopamine, Fluroquinolone, Frusemide, Lactulose, Macrolides, Metoclopramide, Morphine/Pethedine, Nifedipine, NSAIDS, ORS, Penicillins, Prednisolone, Salbutamol, Vancomycin)

3. CLINICAL TRIALS OF DRUG SUBSTANCES. Designing of clinical trials, Types of trials, Choice of patients, Exclusion of patients and Monitoring a clinical trial.

4. EMERGENCY TREATMENT.

PHARMACEUTICS-VIII (Clinical Pharmacy-I)
(Laboratory)

Cr. Hr. 01

Clerkship in the Clinical setting. A project related to Clinical Pharmacy Practices will be completed by the students and will be evaluated by the external examiner.

Recommended Books

1. Roger Walker, Clinical Pharmacy & Therapeutics,
2. Guard Paul, A Behavioral Approach to Pharmacy Practice, Black Well, USA, 2000.
3. Herfindal Gourley, Clinical Pharmacy & Therapeutics,
4. A J Winfield, Pharmaceutical Practice, Churchill Levingstone, London, 2nd Ed.,
5. Kavin Taylor, Pharmacy Practice, Taylor & Francis, New York, 1998.
6. Deborah Rosenbaun, Clinical Research Coordinator Hand Book,
7. Simon Cook, Clinical Studies Management, a Practical Guide to Success,
8. Joseph. T. Dipiro, Encyclopedia of Clinical Pharmacy.
9. Joseph T Dipiro, Encyclopedia of Pharmacy. Marcel Dekker Publishing 2002.
10. Mellainie J Rantucci, Pharmacist Talking with Patients.1997
11. Smith GDG and Aronson J K, Oxford Text Book of Clinical Pharmacology and Drug Therapy, Oxford Universotu Press, UK, 1990.
12. Hansten P and Horn J, Drug interactions. Lee & Febiger, Philadelphia, USA, 1989.

Fourth Professional, First Semester, Pharmaceutics

PHARMACEUTICS-VII (Hospital Pharmacy-I)
(Theory)


Cr. Hr. 03

1. INTRODUCTION

(a) Role of Pharmacist in Hospital.

(b) Minimum standards for pharmacies in Institutions/Hospitals.

(c) Research in Hospital Pharmacy.

2. HOSPITAL AND ITS ORGANIZATION

(a) Classification of Hospitals.

(b) Organizational Pattern.

(c) Administration.

(d) Clinical Departments.

(e) Nursing, Dietectic, Pathology, Blood Bank, Radiology and other supportive services etc.

(f) Role of Pharmacy in Hospital.

(g) Hospital Finances.

3. PHARMACY, ITS ORGANIZATION AND PERSONNEL

(a) Pharmacy specialist.

(b) Drug information Centre.

(c) Poison Control Centre and Antidote Bank.

(d) Pharmacy Education.

(e) Determining the need of Professional and other departmental staff.

(f) Professional services rendered.

4. PHARMACY AND THERAPEUTIC COMMITTEE.

5. THE HOSPITAL FORMULARY

(a) General Principles and guidelines to develop Formulary.

(b) Format.

(c) Preparation of the Formulary & Role of Pharmacist.

(d) Benefits and problems.

(e) Keeping up-to-date Formulary.

(f) Contraceptives.

6. DISPENSING TO INPATIENTS

(a) Methods of Dispensing & SOP’s.

(b) Unit dose dispensing.

(c) Other concepts of dispensing, Satellite Pharmacy etc.

7. DISPENSING TO AMBULATORY PATIENTS.

8. DISTRIBUTION OF CONTROL SUBSTANCES.

9. DISPENSING DURING OFF-HOURS.

10. SAFE USE OF MEDICATION IN THE HOSPITAL

(a) Medication error.

(b) Evaluation & Precautions of Medication Error.

(c) Role of Pharmacist in Controlling Medication Error.

Recommended Books

1. William Hassan, Hospital Pharmacy, Lee & Febiger, Washington, 5th Ed., 1986.
2. N I Bukhari, Hospital Pharmacy, Aziz Book Depot, Lahore-Pakistan, 2000.
3. Martin Stephen, Hospital Pharmacy, Pharmaceutical Press, London, 2003.

Third Professional, Second Semester, Pharmaceutics

PHARMACEUTICS-IV (Community Pharmacy)
(Theory)


Cr. Hr. 04

1. DEFINITIONS AND BACKGROUND.

2. PUBLIC HEALTH AND COMMUNITY PHARMACY: Epidemeology & its Control, Preventive Health (EPI & CDC), Family Planning and Health Policy & National Drug Policy.

3. PATIENT ASSESSMENT.

4. MEDICAL COMPLICATION OF DRUG TAKING: General and Socioeconomic Aspects.

5. PATIENT PHARMACIST COMMUNICATION.

6. PATIENT EDUCATION AND COUNCELLING.

7. CONTROL OF DRUG ABUSE AND MISUSE.

8. ROLE OF PHARMACIST: As Public Health Educator in the Community for Drug Monitoring and Drug Information.

Recommended Books

1. Roy Robertson, Management of Drug Users in the Community: A Practical Handbook.
2. Remington’s Pharmaceutical Sciences, Mack Publishing Company, USA, 2001.
3. Martindale's Extra Pharmacopoeia.