Group IV

Multiple Choice Question (MCQs) of Group IV

1. All members of Group IV has a strong tendency to form inert pair ions except

a. Carbon and Germanium
b. Silicon and Tin
c. Carbon and Silicon
d. Tin and Lead

---------------------
2. Simple carbon compounds are either

a. Linear
b. Planar triangular
c. Tetrahedral
d. All of the above
---------------------
3. All of them can have maximum coordination number of 6 except

a. Carbon
b. Silicon
c. Germanium
d. Tin
-------------------

4. The oxides of carbon and silicon are

a. basic
b. amphoteric
c. acidic
d. none of the above
-------------------
5. The free state of carbon is produced in various forms in nature i.e.

a. coke
b. lampblack
c. charcoal
d. all of the above
-------------------
6. Activated charcoal is used as

a. expectorant
b. astringent
c. germicide
d. adsorbent
-------------------
7. Carbonates of _______ are helpful as antacids.

a. calcium
b. magnesium
c. aluminium
d. all of the above
-------------------
8. Magnesium trisilicate is used as a

a. suspending agent
b. foaming agent
c. flocculating agent
d. all of the above
-------------------
9. Germanium found in bis-beta-carboxy ethyl germanium sesquioxide is purported to have

a. anti-viral activity
b. anti-tumor effect
c. immune system enhancer
d. both b and c
-------------------
10. Tin forms compounds in _________ oxidation state.

a. +2
b. +3
c. +4
d. both a and c
-------------------

Answers to multiple choice questions of Group IV in Inorganic Pharmaceutical Chemistry

1. c
2. d
3. a
4. c
5. d
6. d
7. d
8. a
9. d
10. d

(These MCQs are helpful in the preparation of pharmaceutical chemistry exams)

Further studies:
Essentials of Pharmaceutical Chemistry, 3rd Edition

Wilson & Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry (Wilson and Gisvold's Textbook of Organic and Pharmaceutical Chemistry)

Modern Inorganic Pharmaceutical Chemistry

Texbook of Pharmaceutical Chemistry: Inorganic

Group III

Multiple Choice Question (MCQs) of Group III

1. Sodium borate is a frequent ingredient of

a. Cold creams
b. Eye washes
c. Mouthwashes
d. All of the above
---------------------
2. Third most abundant element is

a. Oxygen
b. Aluminium
c. Silicon
d. Boron
---------------------
3. Aluminium (III) ion is incapable of independent existence in polar solvents due to

a. high charge
b. small diameter
c. electron pair deficiency
d. all of the above
---------------------
4. Soluble aluminium salts are used as

a. deodorants
b. antacids
c. adsorbents
d. suspending agent
---------------------
5. Kaolin is used as

a. adsorbent
b. demulcent
c. suspending agent
d. both a and b
---------------------
6. Insecticides such as ant poisons are made from the compounds of

a. Thallium
b. Boron
c. Aluminium
d. Yttrium
---------------------

Answers to multiple choice questions of Group III in Inorganic Pharmaceutical Chemistry

1. d
2. b
3. d
4. a
5. d
6. a

Group II

Multiple Choice Question (MCQs) of Group II

1. Elements of Group IIA function uniformly in the ______ oxidation state.

a. +1
b. +2
c. +3
d. +4
---------------------
2. The hydroxides of _________ give strongly basic solutions.

a. Calcium
b. Strontium
c. Barium
d. All of the above
---------------------
3. Beryllium metals and its compounds are extremely toxic when

a. ingested
b. inhaled
c. absorbed through the skin
d. all of the above
---------------------
4. Magnesium sulphate can be used as

a. Antacid
b. Cathartic
c. Anticonvulsant
d. Both b and c
---------------------
5. Which of the following is used as lubricant in the preparation of compressed tablets.

a. Magnesium sulphate
b. Magnesium stearate
c. Magnesium hydroxide
d. Magnesium carbonate
---------------------
6. Which of the following is the second most plentiful cation in the cell.

a. Strontium
b. Barium
c. Magnesium
d. Berrylium
---------------------
7. 45Ca isotope has been employed in

a. research involving photosynthesis
b. therapeutically in the treatment of certain malignancies
c. studies involving mineral metabolism
d. diagnostic capacity
---------------------
8. Which of the following is used as a Carbon dioxide absorber.

a. Calcium hydroxide lime
b. Barium hydroxide lime
c. Magnesium hydroxide lime
d. Strontium hydroxide lime
---------------------
9. Volatile metals belong to Group

a. IA
b. IB
c. IIA
d. IIB
---------------------
10. Which of the following element is an essential component of carbonic anhydrase

a. Zinc
b. Magnesium
c. Calcium
d. Beryllium
---------------------
11. In Japan, Itai-Itai disease is believed to caused by drinking contaminated water with

a. Mercury
b. Cadmium
c. Beryllium
d. Barium
---------------------
12. The best antidote for mercury poisoning is

a. Sodium formaldehyde sulfoxylate
b. Calcium gluconate
c. Methiodal sodium
d. Lithium carbonate

---------------------
Answers to multiple choice questions (MCQs) of Group II in Inorganic Pharmaceutical Chemistry
1. b
2. d
3. d
4. d
5. b
6. c
7. c
8. b
9. d
10. a
11. b
12. a

Further Reading:
Inorganic chemistry for pharmacy, ([International textbook company. Blue books] 360-362)

Inorganic chemistry in pharmacy

Chemistry for Pharmacy and the Life Sciences: Including Pharmacology and Biomedical Science

Modern Inorganic Pharmaceutical Chemistry

Group I

Multiple Choice Question (MCQs) of Group I

1. Shells of Group IA and Group IB are represented by

a. (n-1)s2(n-1)p6 and (n-1) s2(n-1)p6ns1 respectively
b. (n-1)s2(n-1)p5 and (n-1) s2(n-1)p6 respectively
c. (n-1)s2(n-1)p6ns1 and (n-1) s2(n-1)d10ns1respectively
d. (n-1)s2(n-1)p6 and (n-1)s2(n-1)d10ns1 respectively
-----------------
2. Which of the followings are rarely hydrated

a. lithium and sodium
b. sodium and potassium
c. lithium and ammonium salts
d. potassium and ammonium salts
-----------------
3. Which of the following statement is true

a. Sodium and potassium both are cations of intracellular fluids
b. Sodium is the cation of intracellular fluid and potassium is the cation of extracellular fluid
c. Sodium and potassium both are cations of extracellular fluids
d. Sodium is the cation of extracellular fluid and potassium is the cation of intracellular fluid
-----------------

4. Sodium ions

a. Promote retention of water in the tissues
b. Should be used with caution in the treatment of cardiac and renal conditions
c. Should be used with caution in edematous conditions
d. All of the above
-----------------

5. Hydrochlorothiazide promote

a. excretion of sodium ions
b. retention of sodium ions
c. excretion of potassium ions
d. retention of potassium ions
-----------------
6. Which of the following has been found valueable in the treatment of hypomanic and manic states

a. Lithium carbonate
b. Lithium phosphates
c. Lithium bromide
d. Lithium chloride

-----------------
7. Which of the following is used as a central depressant

a. Ammonium carbonate
b. Ammonium chloride
c. Ammonium bromide
d. Both b and c

-----------------
8. Coinage metals are elements of Group

a. IA
b. IB
c. IIA
d. IIB
-----------------
9. The respiratory pigment hemocyanin contains

a. Copper
b. Silicon
c. Phosphorus
d. Zinc
-----------------
10. Which of the following is the basis for Fehling’s and Benedict’s solution

a. Copper (I) oxide
b. Copper (I) chloride
c. Copper (II) sulphate
d. Copper (II) oxide
-----------------
11. Which of the following has germicidal activity

a. Silver nitrate
b. Silver sulphadiazine
c. both a and ab
d. None of the above
-----------------
12. Gold salts are characterized by instability to

a. Heat
b. Light
c. Reducing agents
d. All of the above
-----------------
13. Which of the following gold compound can be used in the rheumatoid arthritis

a. Aurothioglucose
b. Gold sodium thiomalate
c. Auranofin
d. All of the above
-----------------

Answers to multiple choice questions of Group I in Inorganic Pharmaceutical Chemistry

1. c
2. d
3. d
4. d
5. c
6. a
7. c
8. b
9. a
10. c
11. c
12. d
13. d

Further reading:
Remington's Pharmaceutical Sciences

Group 0

Multiple Choice Questions in Inorganic Pharmaceutical Chemistry

1. Group 0 represents

a. Inert gases

b. Transition elements

c. Metalloids

d. Alkaline earth metals

-----------

2. The shift in properties in going from halogen to inert gases to alkali metal is shown by valence electron structures as follows

a. (n-1)s2(n-1)p5 --> (n-1)s2(n-1)p6ns1--> (n-1)s2(n-1)p6
b. (n-1)s2(n-1)p6ns1 --> (n-1)s2(n-1)p6 --> (n-1)s2(n-1)p5
c. (n-1)s2(n-1)p5--> (n-1)s2(n-1)p6 --> (n-1)s2(n-1)p6ns1
d. (n-1)s2(n-1)p6 --> (n-1)s2(n-1)p5--> (n-1)s2(n-1)p6ns1
-------------
3.Which of the following Group 0 element don't occur in the atmosphere?

a. Helium
b. Krypton
c. Xenon
d. Radon
-------------
4. Which of the following two is also produced from liquid air by fractional distillation?

a. Argon and radon
b. Xenon and helium
c. Neon and krypton
d. Helium and radon
-------------
5. Which of the following is natural decay product of radium?

a. Neon
b. Krypton
c. Xenon
d. Radon
-------------
6.Synthetic air is prepared from

a. Helium
b. Argon
c. Neon
d. Krypton
--------------

7. Which of the followings can be used in the treatments of certain types of cancer?

a. Krypton
b. Argon
c. Xenon
d. Radon
--------------
8. Which of the following can be used as anesthetics?

a. Helium and argon
b. Argon and krypton
c. Krypton and xenon
d. Neon and Xenon
--------------

Answers to Multiple Choice questions of Group 0 in Inorganic Pharmaceutical Chemistry

1.  a

2. c

3. d

4. c

5. d

6. a

7. d

8. c

Further reading:

Physiological Aspects of Anaesthetics and Inert Gases

The discovery of the inert gases (Chemistry background books, stage 3)

MCQs Chemistry - I.K. s MCQ Series for Medical Entrance Examinations (Includes Pre Solved Papers of Five Years)

Comprehensive MCQs in Chemistry

McQ Tutor: Clinical Chemistry

MCQ tutor for students of clinical chemistry

Introduction

Multiple Choice Questions in Inorganic Pharmaceutical Chemistry

1 .Each atom of an element is described by following 

a .Atomic weight

b. Atomic number

c. Both a and b

d. None of the above

-------------

2. Each electron is assigned 

a. 1 quantum number

b. 2 quantum numbers

c. 3 quantum numbers

d. 4 quantum numbers

------------

3. The subquantum number and magnetic spin quantum number is represented by

a. l and ml respectively

b. n and l respectively

c. n and ml respectively

d. ml and l respectively

-----------

4. Principle quantum number describes

a. Relative position of an energy level with respect to the other energy levels present

b. the different electron distributions possible for a given value of n

c. the magnetic contribution to the angular momentum due to the movement of the electrons in space

d. the magnetic component contributed by the spin of the electron
-------------
5. The permitted values for l and ml are

a. 1,2,3..... and 0,1,2...,(n-1) respectively
b. 0,1,2,3....,(n-1) and -l,.....0,....+l respectively
c. 0,1,2,3,....(n-1) and +-1/2 respectively
d. 1,2,3.... and +-1/2 respectively
-------------
6. The energy required for the removal of electron of least energy is known as

a. Ionization potential
b. Electronegativity
c. Polarization
d. None of the above
--------------
7. _______ have high ionization potentials

a. Metals
b. Metalloids
c. Non-metals
d. both a and b
-------------
8. ________ have high electronegativities

a. Metals
b. Metalloids
c. Non-metals
d. both b and c
-------------
9. The extent of polarization is directly proportional to the difference in

a. Ionization potential
b. Electronegativity
c. Electropositivity
d. Both a and b
--------------
10. Atoms with orbitals occupied by an unshared pair of electrons can share this electron pair with an atom lacking two or more electrons in its valence shell. This bond formed is said to be a

a. Ionic bond
b. Covalent bond
c. Co-ordinate covalent bond
d. Both b and c
---------------
11. Covalent compounds have

a. low melting and high boiling points
b. low m.p. and b.p.
c. high m.p. and low b.p.
d. high m.p. and b.p.
---------------
12. The simple anions are named using

a. -ic
b. -ous
c. -ide
d. -ate
---------------
13. Eka-silicon is now known as

a. Silicon
b. Sulphur
c. Phosphorus
d. Germanium
-------------
14. Orbital electrons are important because

a. They predict the possible oxidation states
b. The shielding of the nuclear charge
c. The polarizability for each element
d. All of the above
--------------

15. Mostly ________ are protein precipitants.

a. Metallic elements
b. Metalloids
c. Non-metallic elements
d. Both a and b

-------------------------------------

Answers to Multiple Choice questions of Introduction in Inorganic Pharmaceutical Chemistry

1. c
2. d
3. a
4. a
5. b
6. a
7. c
8. c
9. b
10. c
11. b
12. c
13. d
14. a
15. d

Further reading:
Modern Inorganic Pharmaceutical Chemistry


Rogers' Inorganic Pharmaceutical Chemistry

A text-book of inorganic pharmaceutical chemistry,

Inorganic medicinal and pharmaceutical chemistry

Comprehensive MCQs in Chemistry

McQ Tutor: Clinical Chemistry

MCQ tutor for students of clinical chemistry

MCQs Chemistry - I.K. s MCQ Series for Medical Entrance Examinations (Includes Pre Solved Papers of Five Years)

p53

p53 helps in the regulation of transcription of variety of genes in response to different type of signals which are related to stress Riley et al.). p53 regulates the GI epithelial cells (Kirsch et al.).

Types of p53:
1. Mutant p53:
This type of p53 is responsible for transformation at 37.5 C whereas at 32.5 C it suppresses transformation working similar as that of wild type p53.

2. Wild type p53:
This type of p53 is not oncogenic and causes prevention of transformation. In human carcinogenesis, this type of p53 work as suppressor gene. (Michalovitz et al.)

p53 Pathway:
It is found to mediate stress responses in the cells. p53 has the ability of initiating repair of DNA, cell cycle arrest, senescence and apoptosis. (Vazquez et al.)

References:
Kirsch et al. (2010), p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis, Science, 327 (5965), 593-596.

Michalovitz et al. (1990), Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53, Cell, 62(4), 671-680

Riley et al. (2008), Transcriptional control of human p53-regulated genes, Nature, 9, 402-431

Vazquez et al. (2008), The genetics of the p53 pathway, apoptosis and cancer therapy, Nat Rev Drug Discov.7(12), 979-987.
Further reading:
The p53 Tumor Suppressor Pathway and Cancer (Protein Reviews, Vol. 2)

TNM classification of malignant tumors

p53 as a Diagnostic Tool for the Detection of Cancer.: An article from: Journal of the Mississippi Academy of Sciences

Telomere shortening is associated with malformation in p53-deficient mice after irradiation during specific stages of development [An article from: DNA Repair]

Prognostic and Predictive Value of p53

Identification and phylogenetic comparison of p53 in two distinct mussel species (Mytilus) [An article from: Comparative Biochemistry and Physiology, Part C]