Diclofenac

Action:

It is more potent in action than naproxen and indomethacin. It is cyclooxygenase inhibitor.

Pharmacokinetics:
It accumulates in the synovial fluid. It is excreted into urine.

Therapeutic Uses:
It is used for the long term treatment of:
• Rheumatoid arthritis
• Osteoarthritis
• And ankylosing spondylitis.

Adverse effects:
Its adverse effects are similar to those of the NSAIDs.