5-HT3 serotonin receptor blockers include Ondansetron and granisetron.
It blocks 5-HT3 receptors in the periphery (visceral afferent fibers) and in the brain (chemorecptor trigger zone).
• Orally or IV
• Prevents vomiting in 50 – 60% of patients treated with Cisplatin.
It is used as prophylaxis of nausea and vomiting associated with cancer chemotherapy.
5-HT1c and 5-HT2 receptor blockers include Ketanserin.
This drug potently blocks vascular α1-adrenoceptors resulting in hypotensive action. It antagonizes platelet aggregation caused by serotonin by blocking 5-HT2 receptors on platelets.
It is used in hypertension and vasospastic conditions.