Sunday, April 17, 2011


Salt form of Atorvastatin is used i.e. atorvastatin calcium. It belongs to a drug calss of Statins.

Mechanism of Action:
It works by inhibiting the enzyme HMG-CoA (Hydroxymethyl glutaryl Coenzyme-A) reductase, which is present in the tissues of the liver and is responsible for the production of cholesterol in the body via mevalonate pathway.

Maximum plasma concentrations is found within 1 to 2 hours. Absorption increases with increasing the dose of the drug. The absolute bioavailability is found to be 14%.
It is used for the treatment of Cholesterol i.e. hyperlipidemia, dyslipidemia and hypercholesterolemia. It is used to reduce the risk of myocardial infarction, stroke and angina.

Side effects:
It may cause diarrhea, apin in extremeties and urinary tract infections.

Brand Names:
  • Atogal (Ingers (Czech Republic))
  • Atorpic
  • Cardyl (Pfizer (Spain))
  • Faboxim (Fabop (Argentina))
  • Hipolixan (Pasteur (Chile))
  • Lipitor (Pfizer, Elea (Argentina))
  • Lipotropic (Drugtech (Chile))
  • Lipovastatinklonal (Klonal (Argentina))
  • Liprimar (Pfizer (Hungary, Ukraine), Goedecke (Russia))
  • Lowden (Saval (Chile))
  • Normalip (Quesada (Argentina))
  • Sincol (Indeco (Argentina))
  • Sortis (Pfizer (Austria, Czech Republic, Germany, Hungary, Poland, Portugal, Switzerland), Godecke (Germany), Parke, Davis (Germany))
  • Sotis
  • Torvacard (Zentiva (Czech Republic, Hungary, Poland, Russia, Ukraine))
  • Torvast (Pfizer (Italy))
  • Totalip (Guidotti (Italy))
  • Tozalip
  • Tulip (Lek (Czech Republic, Russia), Wermar (Mexico), Sandoz (Poland, Ukraine), Pharmacia (Spain))
  • Vastina (Penn (Argentina))
  • Xanator (Sieger (Greece))
  • Xarator (Parke, Davis (Italy))
  • Xavator
  • Zurinel (Prater (Chile))
It is also available in the combination with amlodipine with the name of "Caduet".
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