Sunday, March 6, 2011

Sotalol

It also has a potent non-selective β-blocking agent.

As indicative of β-blocking agents, it also has the ability of decreasing mortality from acute myocardial infarction.

Actions:
It causes the inhibition of potassium outflow (also referred to as delayed rectifier). This inhibition increases both
1. Repolarization and
2. Action potential duration

And have the ability of prolonging the effective refractory period.

It has the ability of suppressing the ectopic beats and decreases myocardial oxygen demand. In the case of myocardial ischemia, it has prominent anti-fibrillatory affect.

Therapeutic uses:
1. Myocardial Ischemia
2. Sustained ventricular tachycardia

Adverse effects:
Prolonging the QT interval leading to torsade de pointes syndrome.
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