Monday, November 10, 2008

Novel and latest types of drugs and drug delivery systems

(WA Check) Newer drug delivery systems are more effective, target specific and more close to nature. Following are some of the novel drug delivery systems:

Products:
1. Radiopharmaceuticals

2. Biotechnology products:
a. Gene therapy
b. Hormones
c. Vaccines
d. Interleukins
e. Monoclonal antibodies
f. Peptides
g. Anti-sense drugs
h. Clotting factors
i. Erythropoietins
j. Colony stimulating factors
k. Tissue plasminogen activator
l. Tyrosine kinase inhibitor
m. Prostaglandins

3. Other techniques and products:
a. Nanocrystal particles
b. Nanogels (Jamie L. Gilmore et al.)
c. Block ionomer complexes (Jamie L. Gilmore et al.)
d. Nanotubes (Jamie L. Gilmore et al.)e. Nanofibers (Jamie L. Gilmore et al.)
f. Magnetic systems (WA Check)
g. Microspheres (Kelvin Hong et al.)
h. Temperature sensitive capsules (Sahraoui Chaieb et al.)
i. Dry powder injection (Terry L. Burkoth et al.)

Delivery systems:
1. Topical administration:
a. Iontophoresis
b. Phonophoresis
c. Controlled release microchips (John T. Santini, Jr., et al.)

2. Oral administration:
a. Mucoadhesive system
b. Osmotic pump

3. Vaginal Administration:
a. Intravaginal drug delivery system
b. Intrauterine progesterone drug delivery system
c. Dinoprostone vaginal insert
d. Estradiol vaginal ring
e. Bioadhesive vaginal gel

4.Ophthalmic products:
a. Inserts


5. Parenteral administration:
a. Liposomes
b. Niosomes
c. Long acting parenteral systems


6. Pegylated Dosage forms

7. Fusion protein

8. Implants

9. Autoinjection systems

References:
Jamie L. Gilmore, Xiang Yi, Lingdong Quan, and Alexander V. Kabanov. Novel Nanomaterials for Clinical Neuroscience. Journal of Neuroimmune Pharmacology. 2008 June; volume 3, Number 2, Pages 83–94.

John T. Santini, Jr.

Kelvin Hong, Afsheen Khwaja, Eleni Liapi, Michael S. Torbenson, Cristos S. Georgiades and Jean-Francois H. Geschwind. New Intra-arterial Drug Delivery System for the Treatment of Liver Cancer: Preclinical Assessment in a Rabbit Model of Liver Cancer. Clinical Cancer Research Volume 12, Pages 2563-2567.

Sahraoui Chaieb


Terry L. Burkoth, Drug delivery by transdermal and transmucosal powder injection

WA Check. New drugs and drug-delivery systems in the year 2000. American Journal of Hospital Pharmacy, Vol 41, Issue 8, Pages 1536-1547.

Further Reading:
Targeted & Controlled Drug Delivery: Novel Carrier Systems by Vyas / Khar

Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches, and Development (Drugs and the Pharmaceutical Sciences) by Edith Mathiowitz, Donald E. Chickering III and Claus-Michael Lehr

Progress in Controlled and Novel Drug Delivery Systems by N. K. Jain

Nanoparticulate Drug Delivery Systems (Drugs and the Pharmaceutical Sciences) by Deepak Thassu, Michel Deleers and Yashwant Pathak

Gene therapy: Gene Therapy: Treating Disease by Repairing Genes (New Biology) by Joseph Ph.D. Panno

Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Third Edition by Nancy Smyth Templeton

Interleukins: Interleukin Protocols (Methods in Molecular Medicine) (Methods in Molecular Medicine) by Luke A. J. Neil and Andrew Bowie

Therapeutic Applications of Interleukin-2 (Basic and Clinical Oncology) by Michael Atkins

Monoclonal Antibodies: Handbook of Therapeutic Monoclonal Antibodies by an Zhiqiang and william strohl

Monoclonal Antibodies: Methods and Protocols (Methods in Molecular Biology) by Maher albitar

Colony stimulating factors: Colony-stimulating Factors by John M. Garland

Fusion Proteins: Antibody Fusion Proteins by Steven M. Chamow and Avi Achkenazi

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