Orexigen and FDA has reached at an agreement about Contrave

Orexigen Therapeutics Inc., Biopharmaceutical Company, has developed a drug for diet and obesity i.e. Contrave.

The company reported on Monday that it has reached at an agreement with U.S. Food and Drug administration (FDA) over the details of design and analysis of the experimental drug.

"We are pleased to receive agreement on the SPA (Special Protocol Assessment) from the FDA after just one cycle of review," said Michael Narachi, President and CEO of Orexigen. "A few months ago, we received detailed written correspondence from the FDA's Director of the Office of New Drugs that identified a clear and feasible path forward for this important potential obesity therapy. We believe the rapid progress we have since made with the FDA's Division of Metabolic and Endocrinologic Products on the detailed protocol and plans for analysis is further indication of the alignment we have reached within the FDA on the requirements for resubmission of the Contrave NDA."

The company will work on 10,000 patients in a placebo-controlled trial to prove that there are very less chances of unacceptable increased adverse cardiovascular events.

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Green tea is beneficial in reducing disabilities; Research

Researchers have worked on more than 45,000 people in the age range of 65 or above for three years and found that these people were more active and have more capability to do daily activities as compared to those who are not green tea drinkers.

This research has been published online in The American Journal of Clinical Nutrition.

"Green tea consumption is significantly associated with a lower risk of incident functional disability, even after adjustment for possible confounding factors," Researchers wrote.

Researchers have found that at least five cups per day consumption can help in reducing disabilities to one third as compared to one cup per day consumption.

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Research: Malaria is more fatal than previous calculations

Researchers have found through recent data and modelling techniques that the number of deaths from malaria in 2010 were 1.24 million as compared to 655,000 million as previously calculated.

The research has been published online in the journal of The Lancet and has been supported by the Bill and Melinda Gates Foundation.

From SayPeople,

Researchers worked on new data and modeling techniques for the development of historical database for malaria between 1980 and 2010. They found that almost 995,000 million people died of malaria in 1980, which rose to its peak in 2004 i.e. 1.82 million deaths and again went down to 1.24 million deaths in 2010. 

Researchers have also found that deaths from malaria increased from 493,000 in Africa in 1980 to 1.61 million in 2004 and then decreased by almost 30% to about 1.13 million in 2010.

Decoding the words in the brain; Research

Researchers from University of Maryland, UC Berkeley and Johns Hopkins University in Baltimore, Maryland have successfully decoded the words in the brain through latest technology.


Researchers have placed electrical rods on the brains of participants and worked with them while the participants were in conversation. They found that brain processes the information in the speed between one to 8000 hertz.


One of the words reproduced by scientists was "Structure".

Prof Robert Knight, one of the researchers from the University of California at Berkeley, said: "This is huge for patients who have damage to their speech mechanisms because of a stroke or Lou Gehrig's disease and can't speak.

"If you could eventually reconstruct imagined conversations from brain activity, thousands of people could benefit."

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Sleep apnea patients can become the patient of silent stroke

Researchers have found that the patients of sleep apnea can become the patients of silent stroke. They have found that there are more chances of white matter lesions in the brain of the patient of sleep apnea.

On the other hand, Researchers have discovered that approximately 91% of patients of stroke also had sleep apnea.

"Sleep apnea is widely unrecognized and still neglected," Dr. Kepplinger of the University of Technology in Dresden, Germany in a news release. "Patients who had severe sleep apnea were more likely to have silent strokes and the severity of sleep apnea increased the risk of being disabled at hospital discharge."

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Dr. Richard Olney died in the course of disease Amyotrophic lateral sclerosis

Dr. Richard Olney (Credit: thirdage)

Dr. Richard Olney who spent 18 years of research in University of California, San Francisco (UCSF) in the research of Amyotrophic Lateral Sclerosis (ALS) has been died on January 27.

He was diagnosed with ALS 8 years ago and resigned from the UCSF ALS center which he established for the treatment and research of ALS in the early years of 1990.

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