Mechanism of action:
It results in vasodilatation by activating guanylate cyclase in the smooth muscles of the arteries. The stimulant is thought to be nitric oxide (NO), which comes from the local oxidation.
It causes a decreased diastolic blood pressure more than systolic blood pressure.
It is absorbed orally. Its half life ranges from 1.5-6 hours.
It is used for moderate to serious hypertension
It is used for acute and chronic congestive heart failure.
It may cause headache, dizziness, malaise, flushing, angina, anorexia, nausea, sweating.
It is contraindicated in patients with coronary artery disease and lupus erythematosus.
It is given in the dose of 40-200 mg/day.