Dipyridamole

It is an anticoagulant. It is a phosphodiesterase inhibitor. It is given in combination with aspirin.

Mechanism of action:
It causes inhibition of cyclic nucleotide phosphodiesterase leading to increased intracellular level of cAMP resulting in decreased Thromboxane A2 synthesis.

It may also stop the reuptake and metabolism of adenosine and potentiates prostacyclin effect to decrease platelet binding to thrombogenic surfaces leading to decreased platelet aggregation.


Therapeutic uses:
It is a coronary vasodilator. It is also used prophylactically in angina pectoris.

Adverse effects:
Headache