Saturday, April 2, 2011

Danaparoid

It is a complex of sulfates of heparin, dermatan and chondroitin. It acts through antithrombin III. It is anti-factor Xa and to a lesser extent it is also inhibitor of thrombin.


Extraction:
It is obtained from porcine mucosa.

Administration and elimination:
It is administered subcutaneously and is eliminated through kidneys.

Therapeutic uses:
Prophylactically, it is used in deep vein thrombosis in hip replacement surgery.

It is effective in Type-II, heparin induced thrombocytopenia.

Adverse effects:
Allergic reactions such as anaphylaxis or asthma may develop. Hemorrhage may occur.

Excess danaparoid can be displaced by plasmapheresis.
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