These are synthetic inhibitors of plasminogen activator with antiplasmin activity.
These are active orally and excreted in urine. Tranexamic acid can cross placenta.
Therapeutic uses:
Aminocaproic acid is effective in the treatment of complications caused by fibrinolysis such as in the treatment of cardiac bypass or major thoracic surgery. It is also found useful in the treatment of subarachnoid hemorrhage and angioedema.
The most important use of tranexamic acid is in the treatment of ovarian tumor which is malignant.
Adverse effects:
They may cause IV thrombosis.
Aminocaproic acid may cause rash, erythema, nausea, diarrhea and heartburn. It also some of the antiadrenergic effects leading to hypotension and nasal stuffiness.
Dosage:
Tranexamic acid is administered as 15mg/kg orallyas a loading dose then 30 mg/kg four times a day.
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