Tuesday, March 22, 2011


It is an aminoglycosides derived from "Streptomyces" bacteria.

It causes disruption in the initiation and elongation steps in protein synthesis by binding to the 30S ribosomal subunit of the the susceptible organism.
Mainly active against extracellular tubercle bacilli as it penetrates poorly into cells.
It is used for the treatment of tuberculsosis.

Adverse effects:It is ototoxic and nephrotoxic. It may also cause vertigo and hearing loss.
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