Monday, March 28, 2011

Mucoadhesive system

Mucoadhesion refers to adhesion with with moist lining in the body passages of mammals containing cells which secrete mucus and opens to the external environment.

Mucoadhesive system refers to the adhesion of natural or synthetic polymer and soft tissues of mucous membrane for an extended period. Cross linked polymer device, containing drug, will adhere to biological membrane and will transfer the drug to the body at the given site, decreasing frequency of administration.

Theories of mucoadhesion:
Following theories have been proposed in the mucoadhesion of the drug:
1. The wetting theory
2. The diffusion theory
3. The electronic theory
4. The adsorption theory
5. The cohesive theory
6. The Fracture theory
7. The mechanical theory
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