Tuesday, March 1, 2011

First Professional, Second Semester, Pharmaceutical Organic Chemistry


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Note: The topics will be taught with special reference to their Pharmaceutical Applications.

1. Stereochemistry: Stereoisomerism, optical isomerism; Molecules with more than one chiral center. Geometrical isomerism, Resolution of racemic mixture. Conformational analysis.

2. Free radicals: Introduction, structure and stability, preparation and properties.

3. General methods of preparations, properties, identification test and pharmaceutical applications of the following classes and their analogues:

Alcohols, Phenols, Ethers, Aldehydes, Ketones, Acids, esters, Amines and Aniline, Lactones, Lactams, Amides, Imides, Diazonium salts.

4. Preparation and properties of medicinally important heterocyclic compounds such as: Pyrrol, Furan, Thiophene, Pyridine, Pyrimidine and Pyrazine.

5. Preparation and properties of heterocyclic compounds in which benzoring is fused with five and six membered ring containing one heteroatom; Indole, Quinoline and Isoquinoline.


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NOTE:- Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g. Organic Preparations like Benzoic acid, Aspirin, Acetanilide, Iodoform, Nitrophenol, 3-nitrophthalic acid, Benzhydrol, 2, 4-Dinitro-chlorobenzene.

Recommended Books

1. Peter Sykes, A guide Book to Mechanism in Organic Chemistry, Longman, New York, 1st Ed., 1991.

2. E L Eliel, Stereochemistry of Carbon Compounds, Tata McGraw-Hill, New Delhi, 1992.

3. Rehman and M. Younis, Organic Chemistry for B.Sc. students, Ilmi Kitab Khana, Lahore, 1997.

4. L Finar, Organic Chemistry Vol I, Person Education Asia, 6th Ed., New Delhi, 2001.

5. Raj K Bansel, Organic Reaction Mechanism, Tata McGraw-Hill, New Delhi, 1992.

6. Furaiss Brian, Practical Organic Chemistry, 5th Ed., ELBS, London.

7. Sykes A P, Guide Book to Mechanism in Organic Chemistry, 5th Ed., Lonsmen Co, UK, 1970.

8. Roberts J D and Caserio M C, Basic Principles of organic Chemistry, 1990.

9. Naser-ud-Din, Introduction to Stereochemistry, Ghafoor Stationery Mart, Peshawar, 1994.

10. Bhal B S, Text Book of Organic Chemistry, S Chand & Co, New Delhi, 14th Ed., 1995.
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