Monday, March 15, 2010

p53

p53 helps in the regulation of transcription of variety of genes in response to different type of signals which are related to stress Riley et al.). p53 regulates the GI epithelial cells (Kirsch et al.).

Types of p53:
1. Mutant p53:
This type of p53 is responsible for transformation at 37.5 C whereas at 32.5 C it suppresses transformation working similar as that of wild type p53.

2. Wild type p53:
This type of p53 is not oncogenic and causes prevention of transformation. In human carcinogenesis, this type of p53 work as suppressor gene. (Michalovitz et al.)

p53 Pathway:
It is found to mediate stress responses in the cells. p53 has the ability of initiating repair of DNA, cell cycle arrest, senescence and apoptosis. (Vazquez et al.)

References:
Kirsch et al. (2010), p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis, Science, 327 (5965), 593-596.

Michalovitz et al. (1990), Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53, Cell, 62(4), 671-680

Riley et al. (2008), Transcriptional control of human p53-regulated genes, Nature, 9, 402-431

Vazquez et al. (2008), The genetics of the p53 pathway, apoptosis and cancer therapy, Nat Rev Drug Discov.7(12), 979-987.
Further reading:
The p53 Tumor Suppressor Pathway and Cancer (Protein Reviews, Vol. 2)

TNM classification of malignant tumors

p53 as a Diagnostic Tool for the Detection of Cancer.: An article from: Journal of the Mississippi Academy of Sciences

Telomere shortening is associated with malformation in p53-deficient mice after irradiation during specific stages of development [An article from: DNA Repair]

Prognostic and Predictive Value of p53

Identification and phylogenetic comparison of p53 in two distinct mussel species (Mytilus) [An article from: Comparative Biochemistry and Physiology, Part C]
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