Tuesday, June 3, 2008


Physical Methods of Encapsulation
1. Spray drying
2. Spray chilling
3. Rotary disk atomization
4. Fluid bed coating
5. Stationary nozzle coextrusion
6. Centrifugal head coextrusion
7. Submerged nozzle coextrusion
8. Pan coating
9. Air Suspension coating
10. Vibrational nozzle

Chemical Methods of Encapsulation
1. Phase separation
2. Solvent evaporation
3. Solvent extraction
4. Interfacial polymerization
5. Simple and complex coacervation
6. In-situ polymerization:
"In situ" means "in place". This is sometimes referred to as in between "in-vivo" and "in-vitro". In-situ polymerization is used to disperse nanocomposites or nanoparticles properly into monomer or monomer solution and the resulting mixture is polymerized. [1]
Examples of nanocomposites prepared by in-situ polymerization:
(Feng Yang et al.)Polyamide 6/silica nanocomposites
(Changchun Zeng et al.) Poly(methyl methacrylate) and Polystyrene/Clay Nanocomposites

7. Liposome technology
8. Nanoencapsulation
9. Matrix polymerization

[1] Page 112, Nanocomposite science and technology by Pulickel M. Ajayan, Linda S. Schadler, Paul V. Braun. 2006.

Changchun Zeng and L. James Lee, Poly(methyl methacrylate) and Polystyrene/Clay Nanocomposites Prepared by in-Situ Polymerization. Macromolecules, 2001, 34 (12), Pages 4098 -4103.

Feng Yang, Yuchun Ou, Zhongzhen Yu. Polyamide 6/silica nanocomposites prepared by in situ polymerization. Journal of Applied Polymer Science, Volume 69 Issue 2, Pages 355 - 361

Further Reading:
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