It is a substituted benzamide and is D2-receptor antagonist.
Mechanism of action:
It acts by blocking dopamine D2-receptor in the chemoreceptor trigger zone in the brain. It also causes increased action of the acetylcholine at muscarinic nerve endings in stomach resulting in more peristalsis and emptying of the upper part of the stomach.
Therapeutic uses:
It is primarily used in nausea and vomiting. It is also used in emptying of the stomach.
Administration and dosage:
It can be administered orally, IM or IV in the dose of 10 mg three times a day.
Adverse effects:
It causes antidopaminergic side effects i.e. twisting of the neck towards one side due to muscle spasm, diarrhea, sedation and extra pyramidal symptoms that are the main adverse effects of dopamine receptor blockers characterized by symptoms very similar to Parkinson’s disease and include tremor.
-
Q: What do you know about ergot alkaloids? Ans: These include alkaloids which we get from the ergot fungus Claviceps purpurea or derived ...
-
Multiple Choice Questions (MCQs) of Powders and Granules from Pharmaceutics 1. _______ powders consist of more than one ingredients. a. Si...
-
(For detailed study of Pharmaceutical Incompatibility Click here) Multiple Choice Questions (MCQs) from Pharmaceutical Incompatibility in ...
No comments:
Post a Comment