Monday, April 11, 2011

Uricosuric agents

The uricosuric drugs are weak organic acids that cause an increased uric acid clearance through kidneys by stoping urate anion exchanger in the proximal convulated tubule of nephron that mediates the reabsorption of urate crystals (i.e. uricosuric agents act at the anionic transport site of renal tubule).
It includes
1. Probenecid
2. Sulfinpyrazone
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