It acts generally as an inhibitor of the tubular secretion of organic acids.
Mechanism of action:
It causes blockage of resorption of uric acid by proximal tubular resorption.
It is used for the treatment of Uric Acid.
It is well absorbed by renal tubules. Its plasma half life is about 5-8.5 hours.
It may show gastric discomfort.
Probenecid stops tubular secretion of penicillin and that is why it sometimes is used for increasing the levels of the antibiotic.
It also inhibits excretion of naproxen, ketoprofen and indomethacin.