Action:
It acts generally as an inhibitor of the tubular secretion of organic acids.
Mechanism of action:
It causes blockage of resorption of uric acid by proximal tubular resorption.
Therapeutic Uses:
It is used for the treatment of Uric Acid.
Pharmacokinetics:
It is well absorbed by renal tubules. Its plasma half life is about 5-8.5 hours.
Adverse effects:
It may show gastric discomfort.
Interaction:
Probenecid stops tubular secretion of penicillin and that is why it sometimes is used for increasing the levels of the antibiotic.
It also inhibits excretion of naproxen, ketoprofen and indomethacin.
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