Monday, March 14, 2011


It is a Hematopoietic growth factor. Darbepoetin is a longer acting type of erythropoietin which differs from erythropoietin in respect of two additional carbohydrate chains. And because of these two additional chains, its biological activity is increased.

Darbepoetin has less value of clearance and have a half life of about three times than that of erythropoietin. It has late start of action and that is why it cannot be used for acute anemia therapy.

Sometimes iron is given along with darbepoetin for a better response. Usually subcutaneous route is superior but in the patients undergoing dialysis of kidney it is given intravenously.

Adverse effects:
It may cause hypertension and arthralgia.
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